Hearing loss

Numerous factors can lead to hearing loss, including noise, disease, genetics, medications, and injury. Wikipedia SNPs associated with risk of hearing loss:

• Noise-induced hearing loss
  • rs2227956
  • rs1043618
  • rs1061581

• Age-related hearing loss
  • Gene Flaw Responsible For Hearing Loss Press release
  • KCNQ4: a gene for age-related hearing impairment? [PMID 16917933]
  • A SNP in GRHL2 associated with age-related hearing impairment [PMID 17921507]

• Medication-induced hearing loss
  • From cisplatin treatment:
    • rs1142345, in the TPMT gene
    • rs12201199, also in the TPMT gene
    • rs9332377, in the COMT gene

• Nonsyndromic hearing loss
  • Connexin 26-related non-sensorineural hearing loss (NSHL) caused by mutations in the GJB2 gene
    • rs80338939, also known as 35delG or as i4000434 by 23andMe, is the most common GJB-2 variant in non-Jewish Europeans
    • rs80338942, also known as 167delT or as i4000435 by 23andMe, is the most common mutation in GJB2 among Ashkenazi Jews
    • rs80338943, also known as 235delC, is the most common GJB2 mutation in Asian populations
  • Other SNPs associated with connexin-related hearing loss
    • rs35594137
    • rs10465885 is also related to early-onset atrial fibrillation (at age 60 or younger) [PMID 21076161]

• Six SNPs in the SLC26A4 gene are associated with Pendred syndrome, as reported by 23andMe:
  • i5012616 (also called L236P) - risk allele C
  • i5000003 (also called E384G) - risk allele G
  • i5012618 (also called T416P) - risk allele C
  • i5000693 (also called V138F) - risk allele T
  • i5000002 (also called H723R) - risk allele G
  • i5000696 (also called L445W) - risk allele G