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rs1006737

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.7 increased risk of Bipolar disorder
(G;G) 0
Make rs1006737(A;G)
ReferenceGRCh38 38.1/141
Chromosome12
Position2236129
GeneCACNA1C
is asnp
is mentioned by
dbSNPrs1006737
ebirs1006737
HLIrs1006737
Exacrs1006737
Varsomers1006737
Maprs1006737
PheGenIrs1006737
hapmaprs1006737
1000 genomesrs1006737
hgdprs1006737
ensemblrs1006737
gopubmedrs1006737
geneviewrs1006737
scholarrs1006737
googlers1006737
pharmgkbrs1006737
gwascentralrs1006737
openSNPrs1006737
23andMers1006737
23andMe allrs1006737
SNP Nexus

SNPshotrs1006737
SNPdbers1006737
MSV3drs1006737
GWAS Ctlgrs1006737
GMAF0.3049
Max Magnitude1.7
? (A;A) (A;G) (G;G) 28

23andMe blog rs1006737 or (rs2159100) Each T at this SNP increased the odds of bipolar disorder by 1.18 times compared to having two CC copies

GWAS snp
PMID [PMID 18711365OA-icon.png]
Trait Bipolar disorder
Title Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Risk Allele A
P-val 7E-8
Odds Ratio 1.18 [NR]
OMIM125480
DescMAJOR AFFECTIVE DISORDER 1; MAFD1
Variant
Relatedalso
OMIM612372
DescMAJOR AFFECTIVE DISORDER 9; MAFD9
Variant
Relatedalso
[PMID 19621016OA-icon.png] The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia

[PMID 19781653] Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individuals


GWAS snp
PMID [PMID 20351715OA-icon.png]
Trait Bipolar disorder and major depressive disorder (combined)
Title Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder
Risk Allele A
P-val 3E-8
Odds Ratio 1.18 [NR] (bipolar)

[PMID 20638048] Genetic variation in CACNA1C, a gene associated with bipolar disorder, influences brainstem rather than gray matter volume in healthy individuals

[PMID 20636642] Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression

[PMID 20679588] Brain function in carriers of a genome-wide supported bipolar disorder variant

[PMID 20819988OA-icon.png] Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness

[PMID 21042317OA-icon.png] Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned


[PMID 21292451] Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder


[PMID 21676128] The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males


[PMID 22012475OA-icon.png] The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder


[PMID 22085483OA-icon.png] The association of genetic variation in CACNA1C with structure and function of a frontotemporal system


[PMID 19388002] Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder.


[PMID 19416921OA-icon.png] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.


[PMID 20098439] CACNA1C (rs1006737) is associated with schizophrenia.


[PMID 20226536] Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.


[PMID 21078228] Effects of a CACNA1C genotype on attention networks in healthy individuals.


[PMID 21395576] No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine.


[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.


[PMID 22665259] The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population.


GET Evidence
rs1006737
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.396825
summary



[PMID 23404764] Association of rs1006737 in CACNA1C with alterations in prefrontal activation and fronto-hippocampal connectivity


[PMID 23406546] The CACNA1C risk allele selectively impacts on executive function in bipolar type I disorder


[PMID 23437284OA-icon.png] CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls

GWAS snp
PMID [PMID 23453885OA-icon.png]
Trait Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)
Title Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Risk Allele
P-val 5E-9
Odds Ratio 1.07 [1.05-1.10]


[PMID 23979604OA-icon.png] A rare mutation of CACNA1C in a patient with bipolar disorder, and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain


[PMID 24108394] Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by CACNA1C and ANK3 Risk Genes for Bipolar Disorder


[PMID 24262814] CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population


[PMID 24269271] The impact of a CACNA1C gene polymorphism on learning and hippocampal formation in healthy individuals: A diffusion tensor imaging study


[PMID 22005930OA-icon.png] Genome-wide association study of Alzheimer's disease with psychotic symptoms.


[PMID 22290120OA-icon.png] The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).


[PMID 22914618] Evidence for the impact of the CACNA1C risk allele rs1006737 on 2-year cognitive functioning in bipolar disorder.


[PMID 23070075OA-icon.png] Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.


[PMID 23437964OA-icon.png] Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in Latinos: a family-based association study.

GWAS snp
PMID [PMID 24280982OA-icon.png]
Trait Schizophrenia or bipolar disorder
Title Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
Risk Allele
P-val 6E-13
Odds Ratio NR NR


[PMID 25124521] Replication of previous genome-wide association studies of psychiatric diseases in a large schizophrenia case-control sample from Spain

GWAS snp
PMID [PMID 23974872OA-icon.png]
Trait Schizophrenia
Title Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
Risk Allele A
P-val 5E-12
Odds Ratio 1.10 [1.08-1.13]


[PMID 25588813] Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta-analysis


[PMID 24643163OA-icon.png] Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding


[PMID 25843436] CACNA1C SNP rs1006737 associates with bipolar I disorder independent of the Bcl-2 SNP rs956572 variant and its associated effect on intracellular calcium homeostasis


[PMID 26048451] CACNA1C risk variant is associated with increased amygdala volume


[PMID 26204268OA-icon.png] Schizophrenia Related Variants in CACNA1C also Confer Risk of Autism


[PMID 26227746] Genetic analysis of SNPs in CACNA1C and ANK3 gene with schizophrenia: A comprehensive meta-analysis


[PMID 26475575] A common risk variant in CACNA1C supports a sex-dependent effect on longitudinal functioning and functional recovery from episodes of schizophrenia-spectrum but not bipolar disorder


[PMID 26541689] CACNA1C polymorphism and altered phosphorylation of tau in bipolar disorder


[PMID 26756527] The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population.


[PMID 27276213] Functional Characterization of Schizophrenia-Associated Variation in CACNA1C.


[PMID 27790829] The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder.