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rs1042173

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) normal
(G;T) normal
(T;T) among alcoholics, likely to be heavier drinkers
ReferenceGRCh38 38.1/141
Chromosome17
Position30197993
GeneSLC6A4
is asnp
is mentioned by
dbSNPrs1042173
ebirs1042173
HLIrs1042173
Exacrs1042173
Varsomers1042173
Maprs1042173
PheGenIrs1042173
hapmaprs1042173
1000 genomesrs1042173
hgdprs1042173
ensemblrs1042173
gopubmedrs1042173
geneviewrs1042173
scholarrs1042173
googlers1042173
pharmgkbrs1042173
gwascentralrs1042173
openSNPrs1042173
23andMers1042173
23andMe allrs1042173
SNP Nexus

SNPshotrs1042173
SNPdbers1042173
MSV3drs1042173
GWAS Ctlgrs1042173
GMAF0.494
Max Magnitude
? (G;G) (G;T) (T;T) 28
rs1042173 is a SNP in the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 SLC6A4 gene.

A study of 275 patients seeking treatment for alcoholism concluded that Caucasians of with the rs1042173(T;T) genotype consumed an average of 11.17 drinks per drinking day, compared with an average of 8.58 for carriers of a rs1042173(G) allele (p = 0.0034). While this held true for both men and women, this association was not seen in Hispanics. [PMID 19032574OA-icon.png]


[PMID 21247998OA-icon.png] Pharmacogenetic Approach at the Serotonin Transporter Gene as a Method of Reducing the Severity of Alcohol Drinking


[PMID 21585624] Association of haplotype combination of serotonin transporter gene polymorphisms with monthly headache days in MOH patients


[PMID 22355291OA-icon.png] Preliminary Evidence for cue-induced Alcohol Craving Modulated by Serotonin Transporter Gene Polymorphism rs1042173.


[PMID 15361494OA-icon.png] Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women.


[PMID 17999363OA-icon.png] Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables.


[PMID 18486105] New evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype.


[PMID 19141529OA-icon.png] Serotonin transporter polymorphisms in patients with portopulmonary hypertension.


[PMID 19199283OA-icon.png] Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples.


[PMID 20395645] Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations.


[PMID 21290142] Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour.


[PMID 23484320] [Relationship between genetic polymorphisms of 3 SNP loci in 5-HTT gene and paranoid schizophrenia]


[PMID 23558235OA-icon.png] Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood trauma


[PMID 23757001OA-icon.png] Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence


[PMID 23290502OA-icon.png] Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers


[PMID 22727904] Sex determines which section of the SLC6A4 gene is linked to obsessive-compulsive symptoms in normal Chinese college students.