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rs10503669

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 associated with higher HDL cholesterol
(A;C) 2 associated with higher HDL cholesterol
(C;C) 0
ReferenceGRCh38 38.1/141
Chromosome8
Position19990179
is asnp
is mentioned by
dbSNPrs10503669
ebirs10503669
HLIrs10503669
Exacrs10503669
Varsomers10503669
Maprs10503669
PheGenIrs10503669
hapmaprs10503669
1000 genomesrs10503669
hgdprs10503669
ensemblrs10503669
gopubmedrs10503669
geneviewrs10503669
scholarrs10503669
googlers10503669
pharmgkbrs10503669
gwascentralrs10503669
openSNPrs10503669
23andMers10503669
23andMe allrs10503669
SNP Nexus

SNPshotrs10503669
SNPdbers10503669
MSV3drs10503669
GWAS Ctlgrs10503669
GMAF0.09275
Max Magnitude2
? (A;A) (A;C) (C;C) 28

Repeatedly associated with elevated lipids according to [PMID 19161620OA-icon.png]

A allele is associated with 2.09mg/dl increase in HDL cholesterol (good cholesterol). [PMID 18193043]

GWAS snp
PMID [PMID 18193043]
Trait HDL cholesterol
Title Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Risk Allele A
P-val 3.9999999999999999E-19
Odds Ratio 2.09 [NR] mg/dl higher
GWAS snp
PMID [PMID 21909109]
Trait
Title Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
Risk Allele T
P-val 7E-39
Odds Ratio 0.0857 [0.073-0.098] mg/dL decrease


[PMID 17903299OA-icon.png] A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 19197348OA-icon.png] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.


[PMID 19474294OA-icon.png] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.


[PMID 19656773OA-icon.png] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.


[PMID 20018038OA-icon.png] Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study.


[PMID 20370913OA-icon.png] Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.


[PMID 21347282OA-icon.png] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.


GET Evidence
rs10503669
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.0625
summary



[PMID 23150898OA-icon.png] Evaluation of seven common lipid associated loci in a large Indian sib pair study