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rs10883365

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1 Normal risk of developing Crohn's disease
(A;G) 1.5 1.2x increased risk for developing Crohn's disease
(G;G) 2 1.62x increased risk for developing Crohn's disease
(T;T) 0
ReferenceGRCh38 38.1/142
Chromosome10
Position99528007
GeneLINC01475
is asnp
is mentioned by
dbSNPrs10883365
ebirs10883365
HLIrs10883365
Exacrs10883365
Varsomers10883365
Maprs10883365
PheGenIrs10883365
hapmaprs10883365
1000 genomesrs10883365
hgdprs10883365
ensemblrs10883365
gopubmedrs10883365
geneviewrs10883365
scholarrs10883365
googlers10883365
pharmgkbrs10883365
gwascentralrs10883365
openSNPrs10883365
23andMers10883365
23andMe allrs10883365
SNP Nexus

SNPshotrs10883365
SNPdbers10883365
MSV3drs10883365
GWAS Ctlgrs10883365
GMAF0.4752
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs10883365 has been reported in a large study to be associated with Crohn's disease.

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.2 (CI 1.03-1.39), and for homozygotes, 1.62 (CI 1.37-1.92). [PMID 17554300OA-icon.png]

[PMID 18936107] The association between rs10883365 and Crohn's disease was replicated in a Japanese population.

GWAS
SNP rs10883365
PubMedID [PMID 17554261OA-icon.png]
Condition Crohn's disease
Gene NKX2-3
Risk Allele
pValue 4.00E-010
OR 1.18
95% CI 1.05-1.32


[PMID 19174780] Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort

OMIM612288
DescINFLAMMATORY BOWEL DISEASE 20; IBD20
Variant
Relatedalso



[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease



[PMID 21514341] Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa

[PMID 18224312OA-icon.png] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.

[PMID 18438406OA-icon.png] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

[PMID 18533027OA-icon.png] Worldwide population differentiation at disease-associated SNPs.

[PMID 18853133OA-icon.png] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

[PMID 19140132OA-icon.png] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

[PMID 19683022] Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease.

[PMID 21049557OA-icon.png] NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.


GET Evidence
rs10883365
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.53125
summary