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rs10988802

From SNPedia

Associated with Chemerin Plasma Levels
Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common in complete genomics
Make rs10988802(A;A)
Make rs10988802(A;G)
ReferenceGRCh38 38.1/141
Chromosome9
Position95614417
is asnp
is mentioned by
dbSNPrs10988802
ebirs10988802
HLIrs10988802
Exacrs10988802
Varsomers10988802
Maprs10988802
PheGenIrs10988802
hapmaprs10988802
1000 genomesrs10988802
hgdprs10988802
ensemblrs10988802
gopubmedrs10988802
geneviewrs10988802
scholarrs10988802
googlers10988802
pharmgkbrs10988802
gwascentralrs10988802
openSNPrs10988802
23andMers10988802
23andMe allrs10988802
SNP Nexus

SNPshotrs10988802
SNPdbers10988802
MSV3drs10988802
GWAS Ctlgrs10988802
GMAF0.1703
Max Magnitude0
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 20237162OA-icon.png]
Trait Plasma chemerin levels
Title Chemerin, a Novel Adipokine in the Regulation of Angiogenesis
Risk Allele
P-val 0.000004
Odds Ratio None None

rs10988802 is a SNP located in the PTCH1 gene. This gene is a member of the patched gene family and a receptor for sonic hedgehog. This gene functions as a tumor suppressor and has a role during embryonic development. Other SNPs in this gene have been associated with various cancers.

rs10988802 was strongly associated with plasma chemerin levels in a genome-wide association study involving 525 patients from the San Antonio Family Heart Study Cohort, originally described here [PMID 20237162OA-icon.png].

Chemerin, also known as retinoic acid receptor responder protein 2 is thought to promote angiogenesis within expanding adipose tissue.