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rs10989591

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common
Make rs10989591(C;T)
Make rs10989591(T;T)
ReferenceGRCh38 38.1/141
Chromosome9
Position101686816
GeneGRIN3A
is asnp
is mentioned by
dbSNPrs10989591
ebirs10989591
HLIrs10989591
Exacrs10989591
Varsomers10989591
Maprs10989591
PheGenIrs10989591
hapmaprs10989591
1000 genomesrs10989591
hgdprs10989591
ensemblrs10989591
gopubmedrs10989591
geneviewrs10989591
scholarrs10989591
googlers10989591
pharmgkbrs10989591
gwascentralrs10989591
openSNPrs10989591
23andMers10989591
23andMe allrs10989591
SNP Nexus

SNPshotrs10989591
SNPdbers10989591
MSV3drs10989591
GWAS Ctlgrs10989591
GMAF0.2998
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs10989591, aka Val362Met or V362M, is a SNP in the N-methyl-D-aspartate 3A GRIN3A gene, which codes for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor. The (C) allele encodes the Val and the (T) allele encodes the Met.

gs278 reflects a gene-gene interaction between this SNP and a DRD2 SNP, rs6277, in which older adults with a particular combination of genotypes at these two (independent) loci are reported to exhibit better episodic memory.

[PMID 17214563] Based on electromagnetic activity during selective attention (auditory oddball task with target processing) measured in 281 healthy subjects, rs10989591(T;T) individuals appeared to show better prefrontal information processing (based on higher frontal P300 amplitudes), presumably reflecting higher NMDA receptor efficacy.