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rs11172113

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.2 0.8x lower risk for migraines
(C;T) 1.1 0.9x lower risk for migraines
Make rs11172113(T;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position57133500
GeneLRP1
is asnp
is mentioned by
dbSNPrs11172113
ebirs11172113
HLIrs11172113
Exacrs11172113
Varsomers11172113
Maprs11172113
PheGenIrs11172113
hapmaprs11172113
1000 genomesrs11172113
hgdprs11172113
ensemblrs11172113
gopubmedrs11172113
geneviewrs11172113
scholarrs11172113
googlers11172113
pharmgkbrs11172113
gwascentralrs11172113
openSNPrs11172113
23andMers11172113
23andMe allrs11172113
SNP Nexus

SNPshotrs11172113
SNPdbers11172113
MSV3drs11172113
GWAS Ctlgrs11172113
GMAF0.3898
Max Magnitude1.2
? (C;C) (C;T) (T;T) 28
rs11172113 is a SNP on ch 12q13.3 in the LRP1 gene.

A large GWAS study of over 5,000 patients with migraines and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk changes on its own. The odds ratio for the less common rs11172113(C) allele was 0.9 (CI: 0.87 - 0.93, p = 4.3 x 10e-9).10.1038/ng.856

GWAS snp
PMID [PMID 21666692OA-icon.png]
Trait
Title Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
Risk Allele T
P-val 4E-9
Odds Ratio 1.1100 [1.08-1.15]


[PMID 22072275OA-icon.png] Genetics of migraine in the age of genome-wide association studies

GWAS snp
PMID [PMID 21946350OA-icon.png]
Trait
Title Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Risk Allele T
P-val 1E-8
Odds Ratio 0.0320 [0.020-0.044] unit decrease
GWAS snp
PMID [PMID 22683712OA-icon.png]
Trait
Title Genome-wide association analysis identifies susceptibility loci for migraine without aura.
Risk Allele
P-val 3E-8
Odds Ratio 1.1600 None
GWAS snp
PMID [PMID 23284291OA-icon.png]
Trait Pulmonary function (interaction)
Title Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Risk Allele
P-val 8E-6
Odds Ratio NR NR


[PMID 24021092] PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients


[PMID 23294458] Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine

GWAS snp
PMID [PMID 23793025OA-icon.png]
Trait Migraine
Title Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Risk Allele
P-val 4E-19
Odds Ratio 1.11 [1.09-1.14]


[PMID 24674449OA-icon.png] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample