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rs1126742

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) normal
(C;T) higher hypertension risk
(T;T) 0 higher hypertension risk
ReferenceGRCh38 38.1/141
Chromosome1
Position46932824
GeneCYP4A11
is asnp
is mentioned by
dbSNPrs1126742
ebirs1126742
HLIrs1126742
Exacrs1126742
Varsomers1126742
Maprs1126742
PheGenIrs1126742
hapmaprs1126742
1000 genomesrs1126742
hgdprs1126742
ensemblrs1126742
gopubmedrs1126742
geneviewrs1126742
scholarrs1126742
googlers1126742
pharmgkbrs1126742
gwascentralrs1126742
openSNPrs1126742
23andMers1126742
23andMe allrs1126742
SNP Nexus

SNPshotrs1126742
SNPdbers1126742
MSV3drs1126742
GWAS Ctlgrs1126742
GMAF0.174
Max Magnitude0
rs1126742 is a SNP in the CYP4A11 gene, which encodes an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans.

In a study of 304 Japanese hypertension patients, rs1126742(C;T) and (T;T) genotypes were significantly (p=0.022) higher than in control individuals.[PMID 18300855]



[PMID 18484194] Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject.


[PMID 22327816] A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease.


GET Evidence
CYP4A11-F434S
aa_change Phe434Ser
aa_change_short F434S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.164157
summary



[PMID 22804341] Haplotype-based case-control study of CYP4A11 gene and myocardial infarction


[PMID 24164311] CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population


[PMID 23085321] Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China.