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From SNPedia

Geno Mag Summary
(C;C) 0 common on affy axiom data
Make rs11549465(C;T)
Make rs11549465(T;T)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs11549465
23andMe allrs11549465
SNP Nexus

GWAS Ctlgrs11549465
Max Magnitude0
? (C;C) (C;T) (T;T) 28

news (T;T) protective against type 1 diabetes

[PMID 19691832OA-icon.png] Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample

[PMID 20412701] Lack of association between hypoxia inducible factor-1 alpha gene polymorphisms and biopsy-proven giant cell arteritis

[PMID 20572162] Single nucleotide polymorphisms in the hypoxia-inducible factor-1 gene and colorectal cancer risk

[PMID 22825513] Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer

[PMID 18035072] Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease.

[PMID 18980686OA-icon.png] Non-synonymous sequence variants within the oxygen-dependent degradation domain of the HIF1A gene are not associated with pre-eclampsia in the Finnish population.

[PMID 18998488] Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas.

[PMID 19306159] Association of hypoxia-inducible factor 1A (HIF1A) gene polymorphisms with systemic sclerosis in a French European Caucasian population.

[PMID 19546348] Genetic variations in the hypoxia-inducible factor-1alpha gene and lung cancer.

[PMID 19602906] Genetic polymorphisms of hypoxia-inducible factor-1 alpha and cardiovascular disease in hemodialysis patients.

[PMID 20005538] Is the interaction between HIF1A P582S and ACTN3 R577X determinant for power/sprint performance?

[PMID 20059631] A multilocus candidate approach identifies ACE and HIF1A as susceptibility genes for cellulite.

[PMID 20299614] A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible factor-1alpha (HIF1A) gene in elite endurance athletes.

[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

[PMID 20540786OA-icon.png] The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients.

[PMID 21778301] The polymorphisms in the VHL and HIF1A genes are associated with the prognosis but not the development of renal cell carcinoma.

[PMID 21791631OA-icon.png] Pharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.

[PMID 23042446OA-icon.png] Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population

GET Evidence
aa_change Pro582Ser
aa_change_short P582S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0871909

[PMID 23631762OA-icon.png] Genotyping analysis and 18FDG uptake in breast cancer patients: a preliminary research

[PMID 24050543] A polymorphism in the 3' untranslated region of Hypoxia-Inducible Factor-1 alpha confers an increased risk of cervical cancer in a Chinese population

[PMID 24090974] The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration

[PMID 24195510] A polymorphism in the 3' untranslated region of Hypoxia-Inducible Factor-1 alpha confers an increased risk of cervical cancer in a Chinese population

[PMID 24232601] Lack of association between the polymorphisms of hypoxia-inducible factor 1A (HIF1A) gene and SLE susceptibility in a Chinese population

[PMID 23583797] 1790 G/A polymorphism, but not 1772 C/T polymorphism, is significantly associated with cancers: an update study.

[PMID 25932084OA-icon.png] The association between the rs11549465 polymorphism in the hif-1α gene and cancer risk: a meta-analysis

[PMID 26113285] Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers

[PMID 26254278OA-icon.png] Impact of VEGF, VEGFR, PDGFR, HIF and ERCC1 gene polymorphisms on thymic malignancies outcome after thymectomy

[PMID 26293784OA-icon.png] Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study

[PMID 27515179] Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial.