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rs11549465

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common on affy axiom data
Make rs11549465(C;T)
Make rs11549465(T;T)
ReferenceGRCh38 38.1/141
Chromosome14
Position61740839
GeneHIF1A
is asnp
is mentioned by
dbSNPrs11549465
ebirs11549465
HLIrs11549465
Exacrs11549465
Varsomers11549465
Maprs11549465
PheGenIrs11549465
hapmaprs11549465
1000 genomesrs11549465
hgdprs11549465
ensemblrs11549465
gopubmedrs11549465
geneviewrs11549465
scholarrs11549465
googlers11549465
pharmgkbrs11549465
gwascentralrs11549465
openSNPrs11549465
23andMers11549465
23andMe allrs11549465
SNP Nexus

SNPshotrs11549465
SNPdbers11549465
MSV3drs11549465
GWAS Ctlgrs11549465
GMAF0.07346
Max Magnitude0
? (C;C) (C;T) (T;T) 28

news (T;T) protective against type 1 diabetes


[PMID 19691832OA-icon.png] Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample


[PMID 20412701] Lack of association between hypoxia inducible factor-1 alpha gene polymorphisms and biopsy-proven giant cell arteritis

[PMID 20572162] Single nucleotide polymorphisms in the hypoxia-inducible factor-1 gene and colorectal cancer risk


[PMID 22825513] Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer


[PMID 18035072] Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease.


[PMID 18980686OA-icon.png] Non-synonymous sequence variants within the oxygen-dependent degradation domain of the HIF1A gene are not associated with pre-eclampsia in the Finnish population.


[PMID 18998488] Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas.


[PMID 19306159] Association of hypoxia-inducible factor 1A (HIF1A) gene polymorphisms with systemic sclerosis in a French European Caucasian population.


[PMID 19546348] Genetic variations in the hypoxia-inducible factor-1alpha gene and lung cancer.


[PMID 19602906] Genetic polymorphisms of hypoxia-inducible factor-1 alpha and cardiovascular disease in hemodialysis patients.


[PMID 20005538] Is the interaction between HIF1A P582S and ACTN3 R577X determinant for power/sprint performance?


[PMID 20059631] A multilocus candidate approach identifies ACE and HIF1A as susceptibility genes for cellulite.


[PMID 20299614] A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible factor-1alpha (HIF1A) gene in elite endurance athletes.


[PMID 20389299OA-icon.png] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.


[PMID 20540786OA-icon.png] The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients.


[PMID 21778301] The polymorphisms in the VHL and HIF1A genes are associated with the prognosis but not the development of renal cell carcinoma.


[PMID 21791631OA-icon.png] Pharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.


[PMID 23042446OA-icon.png] Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population


GET Evidence
HIF1A-P582S
aa_change Pro582Ser
aa_change_short P582S
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0871909
summary



[PMID 23631762OA-icon.png] Genotyping analysis and 18FDG uptake in breast cancer patients: a preliminary research


[PMID 24050543] A polymorphism in the 3' untranslated region of Hypoxia-Inducible Factor-1 alpha confers an increased risk of cervical cancer in a Chinese population


[PMID 24090974] The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration


[PMID 24195510] A polymorphism in the 3' untranslated region of Hypoxia-Inducible Factor-1 alpha confers an increased risk of cervical cancer in a Chinese population


[PMID 24232601] Lack of association between the polymorphisms of hypoxia-inducible factor 1A (HIF1A) gene and SLE susceptibility in a Chinese population


[PMID 23583797] 1790 G/A polymorphism, but not 1772 C/T polymorphism, is significantly associated with cancers: an update study.


[PMID 25932084OA-icon.png] The association between the rs11549465 polymorphism in the hif-1α gene and cancer risk: a meta-analysis


[PMID 26113285] Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers


[PMID 26254278OA-icon.png] Impact of VEGF, VEGFR, PDGFR, HIF and ERCC1 gene polymorphisms on thymic malignancies outcome after thymectomy


[PMID 26293784OA-icon.png] Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study


[PMID 27515179] Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial.