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rs11842874

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.8 common but +17% risk Osteoarthritis
(A;G) 1.2 +17% increased risk for osteoarthritis
(G;G) 1.4 reduced risk for osteoarthritis
ReferenceGRCh38 38.1/141
Chromosome13
Position113040195
GeneMCF2L
is asnp
is mentioned by
dbSNPrs11842874
ebirs11842874
HLIrs11842874
Exacrs11842874
Varsomers11842874
Maprs11842874
PheGenIrs11842874
hapmaprs11842874
1000 genomesrs11842874
hgdprs11842874
ensemblrs11842874
gopubmedrs11842874
geneviewrs11842874
scholarrs11842874
googlers11842874
pharmgkbrs11842874
gwascentralrs11842874
openSNPrs11842874
23andMers11842874
23andMe allrs11842874
SNP Nexus

SNPshotrs11842874
SNPdbers11842874
MSV3drs11842874
GWAS Ctlgrs11842874
GMAF0.1446
Max Magnitude1.8
? (A;A) (A;G) (G;G) 28
rs11842874 is a SNP in the MCF.2 cell line derived transforming sequence-like MCF2L gene on ch 13.

Based initially on a GWAS study of 3,000 patients of European ancestry with osteoarthritis and then subsequently replicated for a total of 19,000+ cases, the rs11842874(A) allele (major allele) was associated with increased risk, at an odds ratio of 1.17 (CI: 1.11–1.23, p = 2.1 × 10e?8). The authors note that MCF2L regulates a nerve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee osteoarthritis patients.10.1016/j.ajhg.2011.08.001

GWAS snp
PMID [PMID 21871595OA-icon.png]
Trait
Title A variant in MCF2L is associated with osteoarthritis.
Risk Allele A
P-val 2E-8
Odds Ratio 1.1700 [1.11-1.23]


[PMID 22615457OA-icon.png] Genetic contribution to radiographic severity in osteoarthritis of the knee.


[PMID 26584642OA-icon.png] Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874