|| +17% increased risk for osteoarthritis
|| reduced risk for osteoarthritis
|| common but +17% risk Osteoarthritis
|?|| (A;A) (A;G) (G;G) ||28|
is a SNP in the MCF.2 cell line derived transforming sequence-like MCF2L
gene on ch 13.
Based initially on a GWAS study of 3,000 patients of European ancestry with osteoarthritis and then subsequently replicated for a total of 19,000+ cases, the rs11842874(A) allele (major allele) was associated with increased risk, at an odds ratio of 1.17 (CI: 1.11–1.23, p = 2.1 × 10e?8). The authors note that MCF2L regulates a nerve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee osteoarthritis patients.10.1016/j.ajhg.2011.08.001
|| [PMID 21871595]
|| A variant in MCF2L is associated with osteoarthritis.
| Risk Allele
| Odds Ratio
|| 1.1700 [1.11-1.23]
[PMID 22615457] Genetic contribution to radiographic severity in osteoarthritis of the knee.
[PMID 26584642] Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874