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rs11931074

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0
Make rs11931074(G;T)
Make rs11931074(T;T)
ReferenceGRCh38 38.1/141
Chromosome4
Position89718364
is asnp
is mentioned by
dbSNPrs11931074
ebirs11931074
HLIrs11931074
Exacrs11931074
Varsomers11931074
Maprs11931074
PheGenIrs11931074
hapmaprs11931074
1000 genomesrs11931074
hgdprs11931074
ensemblrs11931074
gopubmedrs11931074
geneviewrs11931074
scholarrs11931074
googlers11931074
pharmgkbrs11931074
gwascentralrs11931074
openSNPrs11931074
23andMers11931074
23andMe allrs11931074
SNP Nexus

SNPshotrs11931074
SNPdbers11931074
MSV3drs11931074
GWAS Ctlgrs11931074
GMAF0.3545
Max Magnitude0
? (G;G) (G;T) (T;T) 28
GWAS snp
PMID [PMID 19915576]
Trait Parkinson's disease
Title Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Risk Allele G
P-val 7E-17
Odds Ratio 1.37 [1.27-1.48]
OMIM146500
Desc
Variant
Relatedalso


[PMID 21853288] Variant in the 3' region of SNCA associated with Parkinson's disease and serum ?-synuclein levels.


[PMID 19063963OA-icon.png] Genetic susceptibility in Parkinson's disease.


[PMID 19771175OA-icon.png] Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.


[PMID 19915575OA-icon.png] Genome-wide association study reveals genetic risk underlying Parkinson's disease.


[PMID 20070850OA-icon.png] Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.


[PMID 20413655OA-icon.png] Genetics of neurodegenerative diseases: insights from high-throughput resequencing.


[PMID 21391235OA-icon.png] Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.


GET Evidence
rs11931074
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.375
summary



[PMID 23182315] Genetic variants of SNCA and LRRK2 genes are associated with sporadic PD susceptibility: A replication study in a Taiwanese cohort


[PMID 23820587] Alzheimer's disease and Parkinson's disease genome-wide association study top hits and risk of Parkinson's disease in Korean population


[PMID 23853107] Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China


[PMID 23962496OA-icon.png] The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants


[PMID 25427997] SNP rs11931074 of the SNCA gene may not be associated with multiple system atrophy in Chinese population


[PMID 25656566] Alpha-synuclein (SNCA) polymorphisms and susceptibility to Parkinson's disease: A meta-analysis


[PMID 25921825] Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson's disease