|| somewhat reduced risk (~0.5x) for lupus
|| somewhat reduced risk (~0.7x) for lupus
|?|| (A;A) (A;G) (G;G) ||28|
is a SNP in an intergenic region of chromosome 6.
Three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) were associated with systemic lupus erythematosus (SLE) among individuals of European ancestry in a study of 1,200+ patients. For rs13192841, the minor allele was associated with reduced risk (OR 0.72 CI: 0.62–0.83, p = 7.9 × 10e−6. The authors point out that rs13192841 is a "perfect proxy" for rs10499194, which has a similiar reduced risk for rheumatoid arthritis associated with it's minor allele.[PMID 19165919]
An association was found between Systemic lupus erythematosus (SLE) and rs13192841.[PMID 18677310]
|Desc||SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 13; SLEB13|
] Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population
[PMID 19169254] Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
[PMID 19387456] Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.
[PMID 19417005] Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.
[PMID 20018022] Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.
[PMID 20018027] Conditional analysis of the major histocompatibility complex in rheumatoid arthritis.
[PMID 20444755] Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
|| [PMID 21833088]
|| Multiple sclerosis
|| Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
| Risk Allele
| Odds Ratio
|| 1.10 [1.09-1.12]
[PMID 22328738] Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.