Have questions? Visit https://www.reddit.com/r/SNPedia

rs13192841

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.1 somewhat reduced risk (~0.5x) for lupus
(A;G) 2 somewhat reduced risk (~0.7x) for lupus
(G;G) 0 common/normal
ReferenceGRCh38 38.1/141
Chromosome6
Position137646077
is asnp
is mentioned by
dbSNPrs13192841
ebirs13192841
HLIrs13192841
Exacrs13192841
Varsomers13192841
Maprs13192841
PheGenIrs13192841
hapmaprs13192841
1000 genomesrs13192841
hgdprs13192841
ensemblrs13192841
gopubmedrs13192841
geneviewrs13192841
scholarrs13192841
googlers13192841
pharmgkbrs13192841
gwascentralrs13192841
openSNPrs13192841
23andMers13192841
23andMe allrs13192841
SNP Nexus

SNPshotrs13192841
SNPdbers13192841
MSV3drs13192841
GWAS Ctlgrs13192841
GMAF0.1887
Max Magnitude2.1
? (A;A) (A;G) (G;G) 28
rs13192841 is a SNP in an intergenic region of chromosome 6.

Three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) were associated with systemic lupus erythematosus (SLE) among individuals of European ancestry in a study of 1,200+ patients. For rs13192841, the minor allele was associated with reduced risk (OR 0.72 CI: 0.62–0.83, p = 7.9 × 10e−6. The authors point out that rs13192841 is a "perfect proxy" for rs10499194, which has a similiar reduced risk for rheumatoid arthritis associated with it's minor allele.[PMID 19165919OA-icon.png]

An association was found between Systemic lupus erythematosus (SLE) and rs13192841.[PMID 18677310]

OMIM612378
DescSYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 13; SLEB13
Variant
Relatedalso
[PMID 20617138OA-icon.png] Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population


[PMID 19169254OA-icon.png] Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.


[PMID 19387456OA-icon.png] Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.


[PMID 19417005OA-icon.png] Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.


[PMID 20018022OA-icon.png] Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.


[PMID 20018027OA-icon.png] Conditional analysis of the major histocompatibility complex in rheumatoid arthritis.


[PMID 20444755OA-icon.png] Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

GWAS snp
PMID [PMID 21833088OA-icon.png]
Trait Multiple sclerosis
Title Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Risk Allele A
P-val 1E-8
Odds Ratio 1.10 [1.09-1.12]


[PMID 22328738OA-icon.png] Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.