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rs13194504

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 Slightly lower risk for schizophrenia
(A;G) 2 Slightly lower risk for schizophrenia
(G;G) 0 common/normal
ReferenceGRCh38.p2 38.2/146
Chromosome6
Position28662914
GeneZBED9
is asnp
is mentioned by
dbSNPrs13194504
ebirs13194504
HLIrs13194504
Exacrs13194504
Varsomers13194504
Maprs13194504
PheGenIrs13194504
hapmaprs13194504
1000 genomesrs13194504
hgdprs13194504
ensemblrs13194504
gopubmedrs13194504
geneviewrs13194504
scholarrs13194504
googlers13194504
pharmgkbrs13194504
gwascentralrs13194504
openSNPrs13194504
23andMers13194504
23andMe allrs13194504
SNP Nexus

SNPshotrs13194504
SNPdbers13194504
MSV3drs13194504
GWAS Ctlgrs13194504
Max Magnitude2
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 26814963]
Trait Schizophrenia
Title Schizophrenia risk from complex variation of complement component 4.
Risk Allele A
P-val
Odds Ratio

[PMID 26814963]
Sekar et al. (2016) Schizophrenia risk from complex variation of complement component 4 Supplementary Figure 7
Sekar et al. (2016) Schizophrenia risk from complex variation of complement component 4 Supplementary Figure 6b Associations to HLA alleles and coding-sequence polymorphisms

The most strongly associating HLA loci were HLA-B (in primary analyses, Fig. 4a and Extended Data Fig. 6a) and HLA-DRB1 and HLA-DQB1 (in analyses controlling for the signal defined by rs13194504, Fig. 4c and Extended Data Fig. 6b). At these loci, the most strongly associating classical HLA alleles were HLA-B*0801, HLA-DRB1*0301, and HLA-DQB*02, respectively. These HLA alleles are all in strong but partial LD with C4 BS, the most protective of the C4 alleles; they are also in partial LD with the low-risk allele at rs13194505, representing the distinct signal several megabases to the left (Fig. 4). In joint analyses with each of these HLA alleles, genetically predicted C4A expression and rs13194505 continued to associate strongly with schizophrenia, while the HLA alleles did not. In further joint analyses with rs13194504 and genetically predicted C4A expression, 0 of 2,514 tested HLA SNP, amino acid and classical-allele polymorphisms (from ref. 55, including all variants with minor allele frequency (MAF) >0.005) associated with schizophrenia as strongly as rs13194504 or predicted C4A expression did.