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rs13208321

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.36 slight increase in risk for migraine
(A;G) 1.18 slight increase in risk for migraine
(G;G) 0 common/normal
ReferenceGRCh38.p2 38.2/144
Chromosome6
Position96412478
is asnp
is mentioned by
dbSNPrs13208321
ebirs13208321
HLIrs13208321
Exacrs13208321
Varsomers13208321
Maprs13208321
PheGenIrs13208321
hapmaprs13208321
1000 genomesrs13208321
hgdprs13208321
ensemblrs13208321
gopubmedrs13208321
geneviewrs13208321
scholarrs13208321
googlers13208321
pharmgkbrs13208321
gwascentralrs13208321
openSNPrs13208321
23andMers13208321
23andMe allrs13208321
SNP Nexus

SNPshotrs13208321
SNPdbers13208321
MSV3drs13208321
GWAS Ctlgrs13208321
Max Magnitude1.36
? (A;A) (A;G) (G;G) 28
CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

rs13208321 represents a SNP located in chromosomal region 6q16, potentiallly within the FHL5 gene. The FHL5 gene encodes a transcription factor that regulates cAMP responsive elements CREM and CREB6, which play a role in synaptic plasticity and memory formation. However, it is not known if this is associated in any way with the migraine risk associated with this SNP.

[PMID 23793025OA-icon.png] A meta-analysis across 29 GWA studies, including a total of 23,285 migraine cases and 95,425 population-matched controls, found a slight increase in risk for migraine associated with rs13208321(A), (OR 1.18, CI:1.13-1.24, p=2.15 × 10e-12).


[PMID 26231841OA-icon.png] Association of genetic loci for migraine susceptibility in the she people of China