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rs1328674

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) higher risk for RA
(A;G) higher risk for RA
(G;G) 0 average
ReferenceGRCh38 38.1/141
Chromosome13
Position46867572
GeneHTR2A
is asnp
is mentioned by
dbSNPrs1328674
ebirs1328674
HLIrs1328674
Exacrs1328674
Varsomers1328674
Maprs1328674
PheGenIrs1328674
hapmaprs1328674
1000 genomesrs1328674
hgdprs1328674
ensemblrs1328674
gopubmedrs1328674
geneviewrs1328674
scholarrs1328674
googlers1328674
pharmgkbrs1328674
gwascentralrs1328674
openSNPrs1328674
23andMers1328674
23andMe allrs1328674
SNP Nexus

SNPshotrs1328674
SNPdbers1328674
MSV3drs1328674
GWAS Ctlgrs1328674
GMAF0.0528
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs1328675 is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs1328674(A) in dbSNP orientation. The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). This is actually quite close to the odds ratio calculated for rs1328674 by itself; OR of 1.62 (p = 0.007). [PMID 18006541]

Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above should be CACC, rather than CTCC as published.