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rs140068132

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal/common
(A;G) 2.2 lower risk for breast cancer
(G;G) 2.2 lower risk for breast cancer
ReferenceGRCh38 38.1/142
Chromosome6
Position151633699
is asnp
is mentioned by
dbSNPrs140068132
ebirs140068132
HLIrs140068132
Exacrs140068132
Varsomers140068132
Maprs140068132
PheGenIrs140068132
hapmaprs140068132
1000 genomesrs140068132
hgdprs140068132
ensemblrs140068132
gopubmedrs140068132
geneviewrs140068132
scholarrs140068132
googlers140068132
pharmgkbrs140068132
gwascentralrs140068132
openSNPrs140068132
23andMers140068132
23andMe allrs140068132
SNP Nexus

SNPshotrs140068132
SNPdbers140068132
MSV3drs140068132
GWAS Ctlgrs140068132
Max Magnitude2.2
A GWAS study looking at breast cancer in Latina women (~3,000 patients and 8,000 unaffected women) concludes that women with the minor (rarer) form of this SNP, rs140068132, have a significantly lower risk for breast cancer, especially for the estrogen receptor negative form of the disease. The odds ratio in general is 0.60 (CI: 0.53-0.67, p=9 × 10e-18); for estrogen receptor negative or positive disease it is 0.34 (CI: 0.21-0.54) and 0.63 (CI: 0.49-0.80), respectively.[PMID 25327703OA-icon.png]

The minor allele of rs140068132 is also associated with lower mammographic breast density, which is known to have a lower risk for breast cancer (p=0.001).[PMID 25327703OA-icon.png]