Promethease 0.1.82
Rs1426654
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1426654 |
| hapmap | rs1426654 |
| hgdp | rs1426654 |
| ensembl | rs1426654 |
| gopubmed | rs1426654 |
| scholar | rs1426654 |
| rs1426654 | |
| pharmgkb | rs1426654 |
| hgvbaseg2p | rs1426654 |
| medrefsnp | rs1426654 |
| 23andMe | rs1426654 |
| SNP Nexus |
| Gene | SLC24A5 |
| Chromosome | 15 |
| Orientation | plus |
| Position | 46213776 |
| Genotype | Effect |
|---|---|
| rs1426654(A;A) | probably light-skinned, European ancestry |
| rs1426654(A;G) | mixed ancestry likely |
| rs1426654(G;G) | probably darker-skinned, Asian or African ancestry |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs1426654(A;A) | 2.72.7 | probably light-skinned, European ancestry |
| Rs1426654(A;G) | 2.52.5 | mixed ancestry likely |
| Rs1426654(G;G) | probably darker-skinned, Asian or African ancestry |
It appears as if this SNP is a relatively new one in human evolution; one estimate [PMID 17182896] is that the rs1426654(A) allele, in other words, light skin pigmentation, spread through the European population around 6,000 - 12,000 years ago. Prior to that, "European ancestors" were most likely relatively brown-skinned.
This SNP is one of three from the SLC24A5 gene that can be analyzed to categorize the ancestry of a person as either European, African, or Asian, based on a 2009 study.[PMID 19440451]
The 3 SNPs are:
- rs1426654
- rs2555364
- rs16960620
| ? | (A;A) (A;G) (G;G) |
|---|---|
|
| |
Related to SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 4; SHEP4
according to omim 113750. See also
Related to SOLUTE CARRIER FAMILY 24 (SODIUM/POTASSIUM/CALCIUM EXCHANGER), MEMBER
according to omim 609802. See also
