|| some increase in risk for neurodegenerative disorders
|| slight? increase in risk for neurodegenerative disorders
, also known as c.454G>A, p.Ala152Thr and A152T, represents a relatively rare variant in the MAPT
gene on chromosome 17. This variant may also be known as tau-A152.
Publications have linked the rare rs143624519(A) allele to somewhat increased risk for neurodegenerative diseases. As stated here on AlzForum, "Unlike the majority of pathogenic mutations in MAPT, the A152T variant does not appear to cause autosomal-dominant disease. Instead, it acts as a risk modifier and increases susceptibility to several neurodegenerative conditions, including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies". The odds ratios vary between conditions - and publications - but range between about 2 to 6.