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rs1554973

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 increased risk for chorionic plate inflammation
(C;T) increased risk for chorionic plate inflammation
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome9
Position117718534
GeneTLR4
is asnp
is mentioned by
dbSNPrs1554973
ebirs1554973
HLIrs1554973
Exacrs1554973
Varsomers1554973
Maprs1554973
PheGenIrs1554973
hapmaprs1554973
1000 genomesrs1554973
hgdprs1554973
ensemblrs1554973
gopubmedrs1554973
geneviewrs1554973
scholarrs1554973
googlers1554973
pharmgkbrs1554973
gwascentralrs1554973
openSNPrs1554973
23andMers1554973
23andMe allrs1554973
SNP Nexus

SNPshotrs1554973
SNPdbers1554973
MSV3drs1554973
GWAS Ctlgrs1554973
GMAF0.326
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs1554973 is a SNP near the toll-like receptor 4 TLR4 gene.

A study of 109 pregnant women focusing on TLR4 SNPs associated with chorionic plate inflammation concluded that rs1554973 was associated with increased risk when present in the fetal genome. The risk allele's increased odds ratio for clinically significant inflammation was 4.95 (CI: 3.0-5.6, p = .005). [PMID 18928988]


[PMID 19554026OA-icon.png] Genetic association of Toll-like receptor 4 with cervical cytokine concentrations during pregnancy

[PMID 19134200OA-icon.png] No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.

[PMID 20049212OA-icon.png] Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).

[PMID 20200442OA-icon.png] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 21704385OA-icon.png] Interaction between interleukin-1 receptor 2 and Toll-like receptor 4, and cervical cytokines.


[PMID 23161283OA-icon.png] SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?


[PMID 24971461OA-icon.png] Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort


[PMID 25360682OA-icon.png] Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis


[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease