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rs16892766

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
(A;C) 2 slight (~1.5x) increase in colorectal cancer risk
(C;C) 2 slight (~2x) increase in colorectal cancer risk
ReferenceGRCh38 38.1/141
Chromosome8
Position116618444
is asnp
is mentioned by
dbSNPrs16892766
ebirs16892766
HLIrs16892766
Exacrs16892766
Varsomers16892766
Maprs16892766
PheGenIrs16892766
hapmaprs16892766
1000 genomesrs16892766
hgdprs16892766
ensemblrs16892766
gopubmedrs16892766
geneviewrs16892766
scholarrs16892766
googlers16892766
pharmgkbrs16892766
gwascentralrs16892766
openSNPrs16892766
23andMers16892766
23andMe allrs16892766
SNP Nexus

SNPshotrs16892766
SNPdbers16892766
MSV3drs16892766
GWAS Ctlgrs16892766
GMAF0.07208
Max Magnitude2

10.1038/ejhg.2015.72 rs16892766 on 8q23.3 (colorectal cancer OR 1.88, CI: 1.30–2.72, P=0.0007)

? (A;A) (A;C) (C;C) 28
GWAS
SNP rs16892766
PubMedID [PMID 18372905]
Condition Colorectal cancer
Gene EIF3H
Risk Allele A
pValue 3.00E-018
OR 1.27
95% CI 1.20-1.34


OMIM612231
DescCOLORECTAL CANCER, SUSCEPTIBILITY TO, 6; CRCS6
Variant
Relatedalso

[PMID 19843678] Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort



[PMID 20638935] Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype

[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome

[PMID 21119214OA-icon.png] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters

GWAS snp
PMID [PMID 21761138OA-icon.png]
Trait
Title Meta-analysis of new genome-wide association studies of colorectal cancer risk.
Risk Allele
P-val 4E-7
Odds Ratio 1.2400 [1.14-1.34]


[PMID 22367214OA-icon.png] Characterization of gene-environment interactions for colorectal cancer susceptibility loci


[PMID 22532847OA-icon.png] Pooled Sample-Based GWAS: A Cost-Effective Alternative for Identifying Colorectal and Prostate Cancer Risk Variants in the Polish Population


[PMID 19010329] Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.


[PMID 19011631OA-icon.png] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.


[PMID 20501757OA-icon.png] Low-penetrance susceptibility variants in familial colorectal cancer.


[PMID 20648012OA-icon.png] Association studies on 11 published colorectal cancer risk loci.


[PMID 21071539OA-icon.png] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.


[PMID 21314996OA-icon.png] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.


[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.


[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.


GET Evidence
rs16892766
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.101562
summary



[PMID 23359760OA-icon.png] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 22987364] Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers.


[PMID 22999960OA-icon.png] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.


[PMID 23434150OA-icon.png] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?


[PMID 24875374OA-icon.png] Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type


[PMID 25293934] Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility


[PMID 25873010] Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk


[PMID 26885031] Association of 8q23-24 region (8q23.3 loci and 8q24.21 loci) with susceptibility to colorectal cancer: a systematic and updated meta-analysis.