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rs16901979

From SNPedia

risk for prostate cancer
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.9 1.5x increased risk for prostate cancer
(A;C) 2.9 1.5x increased risk for prostate cancer
(C;C) 0 normal risk
ReferenceGRCh38 38.1/141
Chromosome8
Position127112671
is asnp
is mentioned by
dbSNPrs16901979
ebirs16901979
HLIrs16901979
Exacrs16901979
Varsomers16901979
Maprs16901979
PheGenIrs16901979
hapmaprs16901979
1000 genomesrs16901979
hgdprs16901979
ensemblrs16901979
gopubmedrs16901979
geneviewrs16901979
scholarrs16901979
googlers16901979
pharmgkbrs16901979
gwascentralrs16901979
openSNPrs16901979
23andMers16901979
23andMe allrs16901979
SNP Nexus

SNPshotrs16901979
SNPdbers16901979
MSV3drs16901979
GWAS Ctlgrs16901979
GMAF0.18
Max Magnitude2.9
? (A;A) (A;C) (C;C) 28
CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

rs16901979 is a SNP on chromosome 8q24, associated with increased risk for prostate cancer in several studies. In some studies, the regions have been divided, and this SNP falls in region 2.

In a study of over 3,600 Caucasians with prostate cancer, rs16901979 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs16901979(A;A) and (A;C) risk genotypes yield an odds ratio for developing prostate cancer of 1.53 (CI: 1.22-1.92, p=1.8x10e-4) and may account for 3.6% of population attributable risk.10.1056/NEJMoa075819

cancer related according to this blog

Two genetic markers in the 8q24 region of chromosome 8 rs7008482 and rs16901979 have been linked to an increased risk of prostate cancer in African Americans. abstract

In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 2) of advanced prostate cancer.[PMID 18231127OA-icon.png]

A meta-analysis of 10+ studies comprising over 15,000 prostate cancer patients concluded that the odds ratio for rs16901979(A) allele carriers is 1.74 (CI: 1.72-1.77).[PMID 18231127OA-icon.png]

GWAS
SNP rs16901979
PubMedID [PMID 17401366]
Condition Prostate cancer
Gene Intergenic
Risk Allele A
pValue 1.00E-012
OR 1.79
95% CI 1.53-2.11) (EA
Neighborrs10505483
Distance279
[PMID 19549807OA-icon.png] Prostate Cancer Risk Associated Loci in African Americans

[PMID 19562729OA-icon.png] Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry

OMIM611100
DescPROSTATE CANCER, HEREDITARY, 10; HPC10
Variant
Relatedalso
GWAS snp
PMID [PMID 19767754OA-icon.png]
Trait Prostate cancer
Title Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
Risk Allele A
P-val 3E-14
Odds Ratio 1.80 [1.55-2.09]

[PMID 19908238] Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men



[PMID 20564319OA-icon.png] Prostate cancer risk-associated variants reported from genome-wide association studies: Meta-analysis and their contribution to genetic Variation

[PMID 20717903] Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: The flint men's health study

[PMID 21229559] Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry


[PMID 21820706OA-icon.png] Prostate Cancer Risk Alleles and Their Associations With Other Malignancies


[PMID 21756274OA-icon.png] Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men


[PMID 22067658OA-icon.png] Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders


[PMID 22234922OA-icon.png] 8q24 risk alleles in West African and Caribbean men


[PMID 22303333OA-icon.png] Replication of GWAS "Hits" by Race for Breast and Prostate Cancers in European Americans and African Americans


[PMID 22583965] Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population


[PMID 17978284OA-icon.png] Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus.


[PMID 18213635] Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.


[PMID 18274536OA-icon.png] Genome-wide association studies: progress and potential for drug discovery and development.


[PMID 18360876OA-icon.png] Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.


[PMID 18423739] Tumor characteristics of carriers and noncarriers of the deCODE 8q24 prostate cancer susceptibility alleles.


[PMID 18491292OA-icon.png] Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.


[PMID 18577746OA-icon.png] Multiple loci with different cancer specificities within the 8q24 gene desert.


[PMID 18670647OA-icon.png] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.


[PMID 18682823OA-icon.png] Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.


[PMID 18768484OA-icon.png] Family-based samples can play an important role in genetic association studies.


[PMID 18768513OA-icon.png] Common 8q24 sequence variations are associated with Asian Indian advanced prostate cancer risk.


[PMID 18794092OA-icon.png] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.


[PMID 18990762OA-icon.png] Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites.


[PMID 19058137OA-icon.png] Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.


[PMID 19104501OA-icon.png] Prostate cancer genomics: towards a new understanding.


[PMID 19434657OA-icon.png] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.


[PMID 19520795OA-icon.png] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.


[PMID 19528667OA-icon.png] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.


[PMID 19602258OA-icon.png] Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men.


[PMID 20039378OA-icon.png] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.


[PMID 20133699OA-icon.png] Long-range enhancers on 8q24 regulate c-Myc.


[PMID 20584312OA-icon.png] 8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.


[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.


[PMID 20823317OA-icon.png] is-rSNP: a novel technique for in silico regulatory SNP detection.


[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.


[PMID 21445969] Significant associations of prostate cancer susceptibility variants with survival in patients treated with androgen-deprivation therapy.


[PMID 21455501OA-icon.png] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.


[PMID 21557270OA-icon.png] Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry.


[PMID 22382457OA-icon.png] Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis.


[PMID 22561070] 8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().


GET Evidence
rs16901979
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.203125
summary



[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]


[PMID 24345439OA-icon.png] Prostate cancer risk alleles are associated with prostate cancer tumor volume and prostate size


[PMID 22848662OA-icon.png] Polymorphisms on 8q24 are associated with lung cancer risk and survival in Han Chinese.


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 25252079] 8q24 risk alleles and prostate cancer in African-Barbadian men


[PMID 25684153] A simple-to-use method incorporating genomic markers into prostate cancer risk prediction tools facilitated future validation