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rs16906252

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 2
(C;C) 0
(G;G) 0 common/normal
Make rs16906252(A;G)
ReferenceGRCh38 38.1/142
Chromosome10
Position129467281
GeneMGMT
is asnp
is mentioned by
dbSNPrs16906252
ebirs16906252
HLIrs16906252
Exacrs16906252
Varsomers16906252
Maprs16906252
PheGenIrs16906252
hapmaprs16906252
1000 genomesrs16906252
hgdprs16906252
ensemblrs16906252
gopubmedrs16906252
geneviewrs16906252
scholarrs16906252
googlers16906252
pharmgkbrs16906252
gwascentralrs16906252
openSNPrs16906252
23andMers16906252
23andMe allrs16906252
SNP Nexus

SNPshotrs16906252
SNPdbers16906252
MSV3drs16906252
GWAS Ctlgrs16906252
GMAF0.02709
Max Magnitude2
[PMID 17621591] strongly associated with MGMT methylation (multivariate odds ratio 18.0; 95% confidence interval, 6.2-52.1, P < 0.0001) and loss of MGMT expression in colorectal cancer tumors
Neighborrs12269324
Distance925


[PMID 19789298] Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism


[PMID 19734844] MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa


[PMID 20627446] Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP.


[PMID 21355081OA-icon.png] The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas.


[PMID 22975219] The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients


[PMID 24380367OA-icon.png] Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme


[PMID 25910840] The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide


[PMID 27267851] SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer.