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rs17293443

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.5 slightly higher odds of giving birth to fraternal twins
(C;T) 1.5 slightly higher odds of giving birth to fraternal twins
(T;T) 0 common/normal
ReferenceGRCh38.p2 38.2/147
Chromosome15
Position67145525
GeneSMAD3
is asnp
is mentioned by
dbSNPrs17293443
ebirs17293443
HLIrs17293443
Exacrs17293443
Varsomers17293443
Maprs17293443
PheGenIrs17293443
hapmaprs17293443
1000 genomesrs17293443
hgdprs17293443
ensemblrs17293443
gopubmedrs17293443
geneviewrs17293443
scholarrs17293443
googlers17293443
pharmgkbrs17293443
gwascentralrs17293443
openSNPrs17293443
23andMers17293443
23andMe allrs17293443
SNP Nexus

SNPshotrs17293443
SNPdbers17293443
MSV3drs17293443
GWAS Ctlgrs17293443
Max Magnitude1.5
? (C;C) (C;T) (T;T) 28
A meta-analysis found that the less common allele for this SNP, rs17293443(C), is actually associated with a slightly higher likelihood of giving birth to fraternal (dizygotic) twins (odds ratio 1.27, CI:1.19–1.35, p= 1.57 × 10e−8) compared to carriers of the (T) allele. A subsequent replication study of Icelanders yielded lower odds (1.15, CI:1.07–1.23,p=3 × 10e−4).

http://www.cell.com/ajhg/abstract/S0002-9297%2816%2930043-X Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility