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rs174575

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
(C;G)
(G;G)
ReferenceGRCh38 38.1/141
Chromosome11
Position61834531
GeneFADS2
is asnp
is mentioned by
dbSNPrs174575
ebirs174575
HLIrs174575
Exacrs174575
Varsomers174575
Maprs174575
PheGenIrs174575
hapmaprs174575
1000 genomesrs174575
hgdprs174575
ensemblrs174575
gopubmedrs174575
geneviewrs174575
scholarrs174575
googlers174575
pharmgkbrs174575
gwascentralrs174575
openSNPrs174575
23andMers174575
23andMe allrs174575
SNP Nexus

SNPshotrs174575
SNPdbers174575
MSV3drs174575
GWAS Ctlgrs174575
GMAF0.2328
Max Magnitude0
? (C;C) (C;G) (G;G) 28
rs174575, has been investigated with respect to increased intelligence in breastfed children but not yielded any clear result.
  • Although there was no difference in IQ linked to the SNP alone, breastfed children carrying one or two copies of rs174575(C) had a significant (6 point) increase in IQ compared to carriers of the same allele who were not breastfed. For children who were homozygous non-carriers, i.e. rs174575(G;G) individuals, there was no effect of breastfeeding on IQ. [PMID 17984066OA-icon.png]
  • did not replicate those findings. In contrast to their study, (G;G) children exhibited the greatest difference between feeding methods such that breastfed children performed similarly irrespective of child genotype whereas formula fed (G;G) children performed worse than other children on formula milk [PMID 20644632OA-icon.png]

Expanded discussion at http://eurogene.blogspot.com/2011/06/genetic-testing-and-potential-harm-dtc.html


[PMID 20335541] FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk


[PMID 20395685] Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study


[PMID 18936223] Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation.


[PMID 20565855OA-icon.png] Genetic variation in lipid desaturases and its impact on the development of human disease.


[PMID 21040914] FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.


[PMID 21156270] Cognitive function in adolescence: testing for interactions between breast-feeding and FADS2 polymorphisms.


[PMID 21793953] FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.


[PMID 22194195OA-icon.png] Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.

Breastfeeding and IQ


[PMID 23636240] FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants.


[PMID 23737301] A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems.


[PMID 26455892] Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance