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rs1801157

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.4 1.4x higher risk for breast cancer
(A;G) 1.4 1.4x higher risk for breast cancer
(G;G) 0
ReferenceGRCh38 38.1/142
Chromosome10
Position44372809
GeneCXCL12
is asnp
is mentioned by
dbSNPrs1801157
ebirs1801157
HLIrs1801157
Exacrs1801157
Varsomers1801157
Maprs1801157
PheGenIrs1801157
hapmaprs1801157
1000 genomesrs1801157
hgdprs1801157
ensemblrs1801157
gopubmedrs1801157
geneviewrs1801157
scholarrs1801157
googlers1801157
pharmgkbrs1801157
gwascentralrs1801157
openSNPrs1801157
23andMers1801157
23andMe allrs1801157
SNP Nexus

SNPshotrs1801157
SNPdbers1801157
MSV3drs1801157
GWAS Ctlgrs1801157
GMAF0.208
Max Magnitude1.4
rs1801157, also known as G801A, is a SNP in the chemokine (C-X-C motif) ligand 12 CXCL12 gene.
? (A;A) (A;G) (G;G) 28
rs1801157(A) was associated with protection against infection (OR=0.63, P=0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH=0.31, P=0.02) and with death (RH=0.18, P=0.02). [PMID 16177829] HIV-1/AIDS

A 2011 meta-analysis (comprising 5 studies totaling 1,058 cases) found that the rs1801157(A) allele was associated with higher risk for breast cancer, with an odds ratio of 1.44 (CI: 1.2 - 1.7; under a dominant model).[PMID 21643956]


[PMID 19601773] Molecular phenotype of CXCL12beta 3' UTR G801A polymorphism (rs1801157) associated to HIV-1 disease progression

[PMID 19788587OA-icon.png] Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case-control study

[PMID 19821058] Association of the SDF1-3'A polymorphism with susceptibility to myocardial infarction in Chinese Han population


[PMID 19927352] CXCL12 rs1801157 polymorphism in patients with breast cancer, hodgkin's lymphoma, and non-hodgkin's lymphoma


[PMID 20406099] CXCL12-3' G801A Polymorphism Is Not a Risk Factor for Breast Cancer


[PMID 22166550] Association of the-801G/A Polymorphism of CXCL12 Gene with the Risk of Inflammatory Bowel Diseases Development in a Polish Population


[PMID 22699677] CXCL12, CXCR4 and IFNγ genes expression: implications for proinflammatory microenvironment of breast cancer


[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.


[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.


[PMID 17509149OA-icon.png] Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.


[PMID 17848170OA-icon.png] The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.


[PMID 17982648] Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer.


[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.


[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.


[PMID 19115008OA-icon.png] SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19196101] Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19327121] Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 19956101OA-icon.png] Overview of the Rapid Response data.


[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.


[PMID 20041166OA-icon.png] Common genetic variation and the control of HIV-1 in humans.


[PMID 20725607OA-icon.png] CCL3 genotype and current depression increase risk of HIV-associated dementia.


[PMID 21296802] Haplotype analysis of chemokine CXCL12 polymorphisms and susceptibility to premature ovarian failure in Chinese women.


[PMID 21304904OA-icon.png] Genetic predisposition of donors affects the allograft outcome in kidney transplantation; polymorphisms of stromal-derived factor-1 and CXC receptor 4.


[PMID 21584490] SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer.


[PMID 21592819] CXCL12 rs1801157 polymorphism and expression in peripheral blood from breast cancer patients.


[PMID 22962615OA-icon.png] The Role of Genetic Variants of Stromal Cell-Derived Factor 1 in Pediatric HIV-1 Infection and Disease Progression


[PMID 23078136] Stromal-derived factor-1 gene variations in pediatric patients with primary immune thrombocytopenia


[PMID 23653000] CXCL12 and TP53 genetic polymorphisms as markers of susceptibility in a Brazilian children population with acute lymphoblastic leukemia (ALL)


[PMID 23711392] The CXCL12-3'A allele plays a favourable role in patients with multiple myeloma


[PMID 22939870] The CXCL12 G801A polymorphism and cancer risk: evidence from 17 case-control studies.


[PMID 24950177OA-icon.png] A Single Nucleotide Polymorphism in the Stromal Cell-Derived Factor 1 Gene Is Associated with Coronary Heart Disease in Chinese Patients


[PMID 25029540OA-icon.png] Stromal Cell-Derived Factor 1 Gene Polymorphism Is Associated with Susceptibility to Adverse Long-Term Allograft Outcomes in Non-Diabetic Kidney Transplant Recipients


[PMID 25803672OA-icon.png] Variant rs1801157 in the 3'UTR of SDF-1ß Does Not Explain Variability of Healthy-Donor G-CSF Responsiveness


[PMID 25800732] SDF1-3'A polymorphism is associated with size but not occurrence of abdominal aortic aneurysm in a Chinese population


[PMID 25839939] Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic foot ulcer


[PMID 26133117OA-icon.png] Lack of an Association between the SDF-1 rs1801157 Polymorphism and Coronary Heart Disease: A Meta-Analysis