|| Melanoma risk; red hair
|| common in complete genomics
|| Red hair carrier, higher risk of melanoma
, known as Asp84Glu or D84E, is one of several SNPs in the MC1R
gene associated with higher risk of melanoma. [PMID 8894704
The risk allele is rs1805006(A), compared with the wild-type rs1805006(C) allele.
Allelic odds ratio for pale skin(P-value)=5.19(<1.0e-5)MC1R*D84E rs1805006
See also OMIM 155555.0003
[PMID 17999355] A genomewide association study of skin pigmentation in a South Asian population.
[PMID 20670983] The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.