Rs1805007

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is asnp
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dbSNPrs1805007
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hgdprs1805007
ensemblrs1805007
gopubmedrs1805007
scholarrs1805007
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pharmgkbrs1805007
hgvbaseg2prs1805007
medrefsnprs1805007
23andMers1805007
SNP Nexus

GeneMC1R
Chromosome16
Orientationplus
Position88513617
GenotypeEffect
rs1805007(T;T)increased response to anesthetics; 13-20x higher likelihood of red hair
rs1805007(C;T)increased response to anesthetics
rs1805007(C;C)normal risk


Genotypes Magnitude Summary
Rs1805007(C;C) 00 normal risk
Rs1805007(C;T) increased response to anesthetics
Rs1805007(T;T) 33 increased response to anesthetics; 13-20x higher likelihood of red hair

rs1805007, known as Arg151Cys or R151C, one of several SNPs in the MC1R gene associated with red hair color (redheads), and in redheaded females, linked to being more responsive to the anesthetics pentazocine, nalbuphine, and butorphanol, often used by dentists [PMID 9571181, PMID 12663858, PMID 18488028]

The risk allele is rs1805007(T), compared with the wild-type rs1805007(C) allele.

The risk allele has also been reported in several studies to be associated with increased risk for melanoma. For example, an odds ratio of 2.94 (CI: 1.04-8.31) has been reported for an Italian population [PMID 16567973], and similarly an odds ratio of 2.9 has been reported for a Polish population [PMID 16988943].

blog about designing melanocortin analogs specific to these genotypes.

See also OMIM 155555.0004

Neighborrs2228479
Distance177
Neighborrs1805008
Distance27
? (C;C) (C;T) (T;T)
GWAS snp
PMID [PMID 17952075]
Trait Blond vs. brown hair
Title Genetic determinants of hair, eye and skin pigmentation in Europeans
Risk Allele T
P-val 2.0000000000000001E-13
Odds Ratio 2.34 [1.69-3.24]
Related to SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2; SHEP2 according to omim 266300. See also
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