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rs1835740

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1 higher risk for migraine in 1 study which has not replicated
(A;G) 1 unreplicated, higher risk for migraine
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome8
Position97154685
GeneLOC101927066
is asnp
is mentioned by
dbSNPrs1835740
ebirs1835740
HLIrs1835740
Exacrs1835740
Varsomers1835740
Maprs1835740
PheGenIrs1835740
hapmaprs1835740
1000 genomesrs1835740
hgdprs1835740
ensemblrs1835740
gopubmedrs1835740
geneviewrs1835740
scholarrs1835740
googlers1835740
pharmgkbrs1835740
gwascentralrs1835740
openSNPrs1835740
23andMers1835740
23andMe allrs1835740
SNP Nexus

SNPshotrs1835740
SNPdbers1835740
MSV3drs1835740
GWAS Ctlgrs1835740
GMAF0.3343
Max Magnitude1
? (A;A) (A;G) (G;G) 28
rs1835740 is a SNP from the 8q22.1 chromosomal region, best known for harboring various genes involved in glutamate metabolism and transport.

A large study comprising over 5,000 migraine patients and over 10,000 matched controls, primarily from Europe, found that the rs1835740(A) allele conferred a (slightly) higher risk for the disorder. The reported odds ratio was 1.18, (CI: 1.127–1.244, p = 1.69 × 10e-11).[PMID 20802479OA-icon.png]. However this study has failed to replicate in 2 followups.


[PMID 22072275OA-icon.png] Genetics of migraine in the age of genome-wide association studies


[PMID 22103325] A genotype-phenotype analysis of the 8q22.1 variant in migraine with aura


[PMID 21964821OA-icon.png] Genotype-phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1.


[PMID 22908361] A replication study of a GWAS finding in migraine does not identify association in a Spanish case-control sample.


[PMID 24674449OA-icon.png] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample