Have questions? Visit https://www.reddit.com/r/SNPedia

rs2066808

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(T;T) 0
Make rs2066808(C;C)
Make rs2066808(C;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position56344189
GeneSTAT2
is asnp
is mentioned by
dbSNPrs2066808
ebirs2066808
HLIrs2066808
Exacrs2066808
Varsomers2066808
Maprs2066808
PheGenIrs2066808
hapmaprs2066808
1000 genomesrs2066808
hgdprs2066808
ensemblrs2066808
gopubmedrs2066808
geneviewrs2066808
scholarrs2066808
googlers2066808
pharmgkbrs2066808
gwascentralrs2066808
openSNPrs2066808
23andMers2066808
23andMe allrs2066808
SNP Nexus

SNPshotrs2066808
SNPdbers2066808
MSV3drs2066808
GWAS Ctlgrs2066808
GMAF0.1818
Max Magnitude0
? (C;C) (C;T) (T;T) 28
23andMe blog psoriasis

Europeans

  • rs2066808(A) 1.34x risk
GWAS snp
PMID [PMID 19169254OA-icon.png]
Trait Psoriasis
Title Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
Risk Allele A
P-val 1E-9
Odds Ratio 1.34 None


GWAS snp
PMID [PMID 20953190OA-icon.png]
Trait
Title A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
Risk Allele
P-val 2E-7
Odds Ratio 1.4900 [1.28-1.73]


[PMID 21623003OA-icon.png] Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis


[PMID 20154336OA-icon.png] Comprehensive sequence analysis of the human IL23A gene defines new variation content and high rate of evolutionary conservation.


[PMID 21253569OA-icon.png] Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?


GET Evidence
rs2066808
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.242188
summary



[PMID 23579029] Protective effect of interleukin-23A (IL23A) haplotype variants on type 1A diabetes mellitus in a Brazilian population


[PMID 23673284] Association study in Romanians confirms IL23A gene haplotype block rs2066808/rs11171806 as conferring risk to psoriatic arthritis


[PMID 24957500] Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus


[PMID 27893410] Characterization of variations in IL23A and IL23R genes: possible roles in multiple sclerosis and other neuroinflammatory demyelinating diseases.