|| 0.45x reduced risk for breast cancer
|| common on affy axiom data
|?|| (C;C) (C;G) (G;G) ||28|
, also known as Q586H, is a SNP in the nuclear receptor coactivator 3 NCOA3
gene; this gene is also known as SRC-3 or AIB1.
A study of 1,218 familial BRCA1/2-mutation negative breast cancer cases and 1,509 matched controls strengthened a (previously reported) protective effect of rs2230782. The reported odds ratio for rs2230782(C;C) homozygotes is 0.45 (CI: 0.21-0.98).[PMID 20003447]
[PMID 19470168] NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
[PMID 20180986] CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.
|| not reviewed
|| Insufficiently evaluated not reviewed