|?|| (A;A) (A;C) (C;C) ||28|
rs2235544, was associated with the free T3 to free T4 ratio with genome-wide levels of significance (P = 3.6 x 10â€“13). The C-allele of this SNP was associated with increased deiodinase 1 (D1) function with resulting increase in free T3/T4 ratio and free T3 and decrease in free T4 and rT3.
[PMID 18492748] A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.
[PMID 18815314] Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.
|| [PMID 23408906]
|| Thyroid hormone levels
|| A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
| Risk Allele
| Odds Ratio
|| .13 [0.1-0.16] unit increase