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From SNPedia

Geno Mag Summary
(G;G) 0 normal
(T;T) 0 normal
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs2241766
23andMe allrs2241766
SNP Nexus

GWAS Ctlgrs2241766
Max Magnitude0
A study of 733 breast cancer cases for 10 SNPs concluded that the rs2241766(G;T) genotype, in combination with certain genotypes at rs1501299, was at reduced risk (odds ratio 0.61, CI: 0.46-0.80). After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001).[PMID 18451143OA-icon.png]

Adiponectin signaling status was assigned as follows:

rs1501299(G,G) + rs2241766(T,T) = low signaler
rs1501299(G,T) + rs2241766(T,T) = low signaler
rs1501299(G,G) + rs2241766(G,T) = low signaler
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler
rs1501299(G,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,T) = high signaler

Based on these criteria, adiponectin signaling status is now determined by genosets Gs119 and Gs120 for Promethease users.

Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism.

In other words, you are a low adiponectin signaler, and thus possibly at 6-fold higher risk of breast cancer, if you have one of these combinations of alleles:

You are an intermediate adiponectin signaler, and thus possibly at 4-fold higher risk of breast cancer, if you have one of these combinations of alleles:

You are a high adiponectin signaler if you have one of these combinations of alleles:


[PMID 19573164] Association Study and Mutation Analysis of Adiponectin Shows Association of Variants in APM1 with Complex Obesity in Women


[PMID 19696691] Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis

[PMID 19631916] Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese

[PMID 20414354OA-icon.png] Analysis of adiponectin gene polymorphisms in chinese population with systemic lupus erythematosus

[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population

[PMID 20664545] Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

[PMID 21397927OA-icon.png] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk

[PMID 21516303OA-icon.png] Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes

[PMID 21619462] The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer

[PMID 21630088] Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults

[PMID 21637951] A common variant in the adiponectin gene and polycystic ovary syndrome risk

[PMID 21726267] A Meta-analysis on the Association of Adiponectin Gene Polymorphisms with Coronary Heart Disease in Chinese Han Population

[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects

[PMID 22673923] An Association Study of SNP + 45 T > G of the AdipoQ Gene with Type 2 Diabetes in Yi and Han People in China

[PMID 22714914] Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese

[PMID 15616038] Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene.

[PMID 16990411] Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study.

[PMID 17357083OA-icon.png] Medical sequencing at the extremes of human body mass.

[PMID 17712123] Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.

[PMID 18523726OA-icon.png] Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.

[PMID 18548168OA-icon.png] Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18716158OA-icon.png] Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.

[PMID 18776141OA-icon.png] Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.

[PMID 18827209OA-icon.png] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.

[PMID 19035456OA-icon.png] Adipokine genes and prostate cancer risk.

[PMID 19037660OA-icon.png] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.

[PMID 19238139OA-icon.png] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.

[PMID 19661719] Interaction of ADIPOQ genetic polymorphism with blood pressure and plasma cholesterol level on the risk of coronary artery disease.

[PMID 19755407OA-icon.png] Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women.

[PMID 19912668OA-icon.png] Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study.

[PMID 20201642] Associations of polymorphisms in adiponectin and leptin genes with men's longevity.

[PMID 20230294] Analysis of adiponectin gene polymorphisms in dilated cardiomyopathy in a Han Chinese population.

[PMID 20848215] Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.

[PMID 21054480] Genetic effects of adiponectin on blood lipids and blood pressure.

[PMID 21219602OA-icon.png] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.

[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.

[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.

[PMID 22070425] Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.

[PMID 22386722] Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.

[PMID 22391941] Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.

[PMID 22583123OA-icon.png] Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.

[PMID 23041095] Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction

[PMID 23118546OA-icon.png] Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population

[PMID 23143890] Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis

[PMID 23151860] +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia

[PMID 23200411] ADIPOQ gene polymorphisms and cancer risk: A meta-analysis

[PMID 23370338] Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure

[PMID 23653335] AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study

[PMID 23658423] Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals

[PMID 23740135] The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk

[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia

[PMID 23260797] Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes

[PMID 23805506] [Association of adiponectin gene polymorphrism with metabolic syndrome in older Han adults from major cities in China]

[PMID 23819115OA-icon.png] Association of Atherosclerotic Peripheral Arterial Disease with Adiponectin Genes SNP+45 and SNP+276: A Case-Control Study

[PMID 23826253OA-icon.png] Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study

[PMID 23972466] Association Between the Adiponectin +45T>G Genotype and Risk of Cardiovascular Disease: A Meta-analysis

[PMID 24293390] An updated meta-analysis of the association between ADIPOQ rs2241766 polymorphism and colorectal cancer

[PMID 24559720] Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome

[PMID 23065236] The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies.

[PMID 23144319] Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.

[PMID 23144325OA-icon.png] P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.

[PMID 23552441] Association of adiponectin gene polymorphism with birth weight in Korean neonates.

[PMID 24894086] Adiponectin gene (ADIPOQ) polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type 2 diabetes

[PMID 25074391] Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents

[PMID 25135112] Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses

[PMID 25223469] Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis

[PMID 26329379OA-icon.png] Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer

[PMID 26546898] Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population

[PMID 26884098] Single Nucleotide Polymorphism (SNP) in the Adiponectin Gene and Cardiovascular Disease.

[PMID 26887769] [Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].

[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.