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rs2283228

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs2283228(A;C)
Make rs2283228(C;C)
ReferenceGRCh38 38.1/141
Chromosome11
Position2828300
GeneKCNQ1
is asnp
is mentioned by
dbSNPrs2283228
ebirs2283228
HLIrs2283228
Exacrs2283228
Varsomers2283228
Maprs2283228
PheGenIrs2283228
hapmaprs2283228
1000 genomesrs2283228
hgdprs2283228
ensemblrs2283228
gopubmedrs2283228
geneviewrs2283228
scholarrs2283228
googlers2283228
pharmgkbrs2283228
gwascentralrs2283228
openSNPrs2283228
23andMers2283228
23andMe allrs2283228
SNP Nexus

SNPshotrs2283228
SNPdbers2283228
MSV3drs2283228
GWAS Ctlgrs2283228
GMAF0.1804
Max Magnitude0
? (A;A) (A;C) (C;C) 28

nature type-2 diabetes

  • rs2283228 (additive model P = 3.1 times 10-12; OR = 1.26, 95% CI = 1.18–1.34).


[PMID 19516902OA-icon.png] The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load


[PMID 19575309] Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population

OMIM125853
DescDIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
Variant
Relatedalso
[PMID 22479571OA-icon.png] Several Polymorphisms of KCNQ1 Gene Are Associated with Plasma Lipid Levels in General Chinese Populations


[PMID 22206064] KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects


[PMID 18711366] SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.


[PMID 19252135OA-icon.png] Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.


[PMID 19448982OA-icon.png] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China.


[PMID 19502414OA-icon.png] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.


[PMID 20701788OA-icon.png] KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.


[PMID 23271129] Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes


[PMID 23786590] Common Variants in KCNQ1 Confer Increased Risk of Type 2 Diabetes and Contribute to the Diabetic Epidemic in East Asians: A Replication and Meta-Analysis


[PMID 22696034] KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes.


[PMID 23107108] Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs.