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rs25532

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) may be part of a haplotype associated with OCD
(C;T) may be part of a haplotype associated with OCD
(T;T) normal
ReferenceGRCh38 38.1/142
Chromosome17
Position30237152
GeneSLC6A4
is asnp
is mentioned by
dbSNPrs25532
ebirs25532
HLIrs25532
Exacrs25532
Varsomers25532
Maprs25532
PheGenIrs25532
hapmaprs25532
1000 genomesrs25532
hgdprs25532
ensemblrs25532
gopubmedrs25532
geneviewrs25532
scholarrs25532
googlers25532
pharmgkbrs25532
gwascentralrs25532
openSNPrs25532
23andMers25532
23andMe allrs25532
SNP Nexus

SNPshotrs25532
SNPdbers25532
MSV3drs25532
GWAS Ctlgrs25532
GMAF0.06336
Max Magnitude
rs25532 is a SNP in a regulatory region upstream of the serotonin transporter SLC6A4 gene. The more common allele, rs25532(C), is the higher-expressing allele.

A study of patients with obsessive compulsive disorder (OCD) concluded that the major allele of rs25532 was a major contributor to the association of a corresponding haplotype with this disorder. [PMID 18055562]



[PMID 18444253OA-icon.png] Additional functional variation at the SLC6A4 gene.


[PMID 18824000OA-icon.png] How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.


[PMID 23510579] Worldwide population variation and haplotype analysis at the serotonin transporter gene SLC6A4 and implications for association studies.


[PMID 23630162OA-icon.png] Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.