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rs28371685

From SNPedia

Warfarin (Coumadin®)
Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) carrier of one CYP2C9*11 allele
(T;T) 2.5 CYP2C9*11 homozygote
ReferenceGRCh38 38.1/142
Chromosome10
Position94981224
GeneCYP2C9
is asnp
is mentioned by
dbSNPrs28371685
ebirs28371685
HLIrs28371685
Exacrs28371685
Varsomers28371685
Maprs28371685
PheGenIrs28371685
hapmaprs28371685
1000 genomesrs28371685
hgdprs28371685
ensemblrs28371685
gopubmedrs28371685
geneviewrs28371685
scholarrs28371685
googlers28371685
pharmgkbrs28371685
gwascentralrs28371685
openSNPrs28371685
23andMers28371685
23andMe allrs28371685
SNP Nexus

SNPshotrs28371685
SNPdbers28371685
MSV3drs28371685
GWAS Ctlgrs28371685
GMAF0.006428
Max Magnitude2.5
? (C;C) (C;T) (T;T) 28
CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

rs28371685, also known as 1003C>T, 42542C>T or R335W is a SNP in the CYP2C9 gene.

The rs28371685(T) allele defines the CYP2C9*11 variant, which has decreased activity.

According to a 23andMe discussion This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected rs4420638, rs34276300, rs3091244, rs34601266, rs2033003, rs7900194, rs9332239, rs28371685, rs1229984, and rs28399504.


[PMID 20214591] Pharmacogenomics in aspirin intolerance



[PMID 18466099OA-icon.png] Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.


[PMID 18752379OA-icon.png] Warfarin pharmacogenetics.


[PMID 23133420OA-icon.png] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.