rs28371685

Warfarin (Coumadin®)

plus

Geno	Mag	Summary
(C;C)	0	normal
(C;T)		carrier of one CYP2C9*11 allele
(T;T)	2.5	CYP2C9*11 homozygote

Reference

GRCh38 38.1/142

Chromosome

10

Position

94981224

Gene

CYP2C9

is a	snp
is	mentioned by
dbSNP	rs28371685
dbSNP (classic)	rs28371685
ClinGen	rs28371685
ebi	rs28371685
HLI	rs28371685
Exac	rs28371685
Gnomad	rs28371685
Varsome	rs28371685
LitVar	rs28371685
Map	rs28371685
PheGenI	rs28371685
Biobank	rs28371685
1000 genomes	rs28371685
hgdp	rs28371685
ensembl	rs28371685
geneview	rs28371685
scholar	rs28371685
google	rs28371685
pharmgkb	rs28371685
gwascentral	rs28371685
openSNP	rs28371685
23andMe	rs28371685
SNPshot	rs28371685
SNPdbe	rs28371685
MSV3d	rs28371685
GWAS Ctlg	rs28371685

GMAF

0.006428

Max Magnitude

2.5

?

(C;C) (C;T) (T;T)

28

rs28371685, also known as 1003C>T, 42542C>T or R335W is a SNP in the CYP2C9 gene.

The rs28371685(T) allele defines the CYP2C9*11 variant, which has decreased activity.

According to a 23andMe discussion This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected rs4420638, rs34276300, rs3091244, rs34601266, rs2033003, rs7900194, rs9332239, rs28371685, rs1229984, and rs28399504.

[PMID 20214591] Pharmacogenomics in aspirin intolerance

[PMID 18466099 ] Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.

[PMID 18752379 ] Warfarin pharmacogenetics.

[PMID 23133420 ] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.