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rs3093061

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 normal risk
(A;G) normal risk?
(G;G) 0.37-0.49x reduced risk for SLE
ReferenceGRCh38 38.1/142
Chromosome1
Position159715192
GeneCRP
is asnp
is mentioned by
dbSNPrs3093061
ebirs3093061
HLIrs3093061
Exacrs3093061
Varsomers3093061
Maprs3093061
PheGenIrs3093061
hapmaprs3093061
1000 genomesrs3093061
hgdprs3093061
ensemblrs3093061
gopubmedrs3093061
geneviewrs3093061
scholarrs3093061
googlers3093061
pharmgkbrs3093061
gwascentralrs3093061
openSNPrs3093061
23andMers3093061
23andMe allrs3093061
SNP Nexus

SNPshotrs3093061
SNPdbers3093061
MSV3drs3093061
GWAS Ctlgrs3093061
Max Magnitude0
rs3093061 is a SNP in the promoter of the C-reactive protein CRP gene.

[PMID 18182444] rs3093061 associated with SLE and functional haplotypes containing rs3091244/rs3093062

A study of ~1,000 patients with systemic lupus erythematosus found that in both populations (Caucasian and African-American) studied, the rs3093061(G;G) genotype had a significantly reduced risk compared to the more common (A;A) genotype. In African-Americans, the odds ratio was 0.49 (CI: 0.37-0.65, p=6.4x10e-7), and in Caucasians, the odds ratio was 0.37 (CI: 0.24-0.56, p=2.3x10e-6).

Neighborrs3093062
Distance298
Neighborrs3093059
Distance154
Neighborrs2794521
Distance114
OMIM613145
Desc
Variant
Relatedalso
[PMID 18216863OA-icon.png] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.