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rs3130340

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0
Make rs3130340(C;C)
Make rs3130340(C;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position32276850
is asnp
is mentioned by
dbSNPrs3130340
ebirs3130340
HLIrs3130340
Exacrs3130340
Varsomers3130340
Maprs3130340
PheGenIrs3130340
hapmaprs3130340
1000 genomesrs3130340
hgdprs3130340
ensemblrs3130340
gopubmedrs3130340
geneviewrs3130340
scholarrs3130340
googlers3130340
pharmgkbrs3130340
gwascentralrs3130340
openSNPrs3130340
23andMers3130340
23andMe allrs3130340
SNP Nexus

SNPshotrs3130340
SNPdbers3130340
MSV3drs3130340
GWAS Ctlgrs3130340
GMAF0.2498
Max Magnitude0
? (C;C) (C;T) (T;T) 28

rs3130340 increases susceptibility to Bone mineral density variations, lower for carriers of the T allele [PMID 18445777]

rs3130340 increases susceptibility to Osteoporotic fractures for carriers of the T allele [PMID 18445777]

GWAS
SNP rs3130340
PubMedID [PMID 18445777]
Condition Bone mineral density (spine)
Gene MHC, C6orf10
Risk Allele T
pValue 1.00E-007
OR 0.1
95% CI 0.06-0.13) SD decreas



[PMID 21646926] Interactions of osteoporosis candidate genes for age at menarche, age at natural menopause, and maximal height in Han Chinese women


[PMID 22370887OA-icon.png] Are bone mineral density loci associated with hip osteoporotic fractures? A validation study on previously reported genome-wide association loci in a Chinese population


[PMID 19181680OA-icon.png] Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.


[PMID 20018075OA-icon.png] Genome-wide association study of rheumatoid arthritis by a score test based on wavelet transformation.


GET Evidence
rs3130340
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.203125
summary