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rs34516635

From SNPedia

Longevity and height for Ashkenazi Jewish women.
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.5 Possibly increased longevity for Ashkenazi Jewish women.
(A;G) 1.5 Possibly increased longevity for Ashkenazi Jewish women.
(G;G) 1.1 Less longevity for Ashkenazi Jewish women.
ReferenceGRCh38 38.1/141
Chromosome15
Position98908747
GeneIGF1R
is asnp
is mentioned by
dbSNPrs34516635
ebirs34516635
HLIrs34516635
Exacrs34516635
Varsomers34516635
Maprs34516635
PheGenIrs34516635
hapmaprs34516635
1000 genomesrs34516635
hgdprs34516635
ensemblrs34516635
gopubmedrs34516635
geneviewrs34516635
scholarrs34516635
googlers34516635
pharmgkbrs34516635
gwascentralrs34516635
openSNPrs34516635
23andMers34516635
23andMe allrs34516635
SNP Nexus

SNPshotrs34516635
SNPdbers34516635
MSV3drs34516635
GWAS Ctlgrs34516635
Max Magnitude1.5
rs34516635 is one of a small number of (rare) SNPs in the IGF1R gene found in a study of 384 Ashkenazi centenarians to potentially be associated with longevity and ageing. The rs34516635(A) allele was found somewhat more frequently (p=0.02) in female centenarians than in controls. No association was found for males. Higher IGF1 levels and an average decrease in maximal lifetime height of 2.5cm were also reported to be associated with (female Ashkenazi) centenarians.[PMID 18316725OA-icon.png]


[PMID 20625407OA-icon.png] A comprehensive in silico analysis of the functional and structural impact of SNPs in the IGF1R gene.


ClinVar
Risk rs34516635(A;A)
Alt rs34516635(A;A)
Reference rs34516635(G;G)
Significance Probable-non-pathogenic
Disease not specified
Variation info
Gene IGF1R
CLNDBN not specified
Reversed 0
HGVS NC_000015.9:g.99451976G>A
CLNSRC
CLNACC RCV000179350.1,