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rs3736309

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) normal
(A;G) 2 0.44x decreased risk for chronic obstructive pulmonary lung disease
(G;G) 2 0.44x decreased risk for chronic obstructive pulmonary lung disease
ReferenceGRCh38 38.1/141
Chromosome12
Position49964271
GeneAQP5, LOC101927318
is asnp
is mentioned by
dbSNPrs3736309
ebirs3736309
HLIrs3736309
Exacrs3736309
Varsomers3736309
Maprs3736309
PheGenIrs3736309
hapmaprs3736309
1000 genomesrs3736309
hgdprs3736309
ensemblrs3736309
gopubmedrs3736309
geneviewrs3736309
scholarrs3736309
googlers3736309
pharmgkbrs3736309
gwascentralrs3736309
openSNPrs3736309
23andMers3736309
23andMe allrs3736309
SNP Nexus

SNPshotrs3736309
SNPdbers3736309
MSV3drs3736309
GWAS Ctlgrs3736309
GMAF0.1561
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs3736309 is a SNP in the aquaporin 5 (AQP5) gene. Among other roles, the aquaporin proteins play a critical role in the maintenance of normal lung water homeostasis.

A study of 332 Chinese Han Chronic obstructive pulmonary disease (COPD) patients and 373 unrelated, age-matched controls concluded that carriers of a rs3736309(G) allele had a lower risk of COPD than rs3736309(A;A) carriers, with an odds ratio of 0.44 (CI: 0.307-0.631). [PMID 18853286]


[PMID 23352976] Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor alpha in patients with Meniere's disease and sudden sensorineural hearing loss.