[PMID 18855532] among 120 (likely Japanese) first-episode neuroleptic-naive schizophrenics treated with risperidone genotyped for 30 variants in misc. dopamine and serotonin (receptors and otherwise) two SNPs in DRD2 (rs1799989 and rs1800497) and two SNPs in AKT1 (rs3803300 and rs2494732) were significant predictors of treatment response to risperidone
The ancestral allele is G in the dbSNP database.
[PMID 22277669] Genetic overlap between schizophrenia and bipolar disorder: A study with AKT1 gene variants and clinical phenotypes
[PMID 16260726] Detection of functional single-nucleotide polymorphisms that affect apoptosis.
[PMID 16395129] Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population.
[PMID 17464696] AKT1 and neurocognition in schizophrenia.
[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
[PMID 19931325] No association between AKT1 polymorphism and schizophrenia: a case-control study in a Korean population and a meta-analysis.
[PMID 20046382] AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia.
[PMID 21842521] AKT1 polymorphisms and survival of early stage non-small cell lung cancer.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 25060489] Genetic variants in AKT1 gene were associated with risk and survival of OSCC in Chinese Han Population
[PMID 26988277] Genetic Association of Curative and Adverse Reactions to Tyrosine Kinase Inhibitors in Chinese advanced Non-Small Cell Lung Cancer patients.
[PMID 27305091] Genetic Association of TCF4 and AKT1 Gene Variants with the Age at Onset of Schizophrenia.