From SNPedia
rs3803662, a SNP associated with the TNRC9 gene, was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 breast cancer samples.[PMID 17529967]
[PMID 17529974] rs3803662(T;T) have a 1.64-fold greater risk of estrogen receptor-positive tumors
In a study of 1,267 breast cancer patients, rs3803662 heterozygote carriers and minor allele homozygote carriers were more likely to be diagnosed before the age of 60 years (p = 0.025) relative to major allele homozygote carriers.[PMID 17997823]
[PMID 18437204] breast cancer
- rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21))
[PMID 19005751] rs3803662 confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.15, p(allelic) = 5.1 x 10e-2) for breast cancer
| ? | (C;C) (C;T) (T;T) |
|---|
 |
| GWAS
|
| SNP
| rs3803662
|
| PubMedID
| [PMID 17529974]
|
| Condition
| Breast cancer
|
| Gene
| TNRC9
|
| Risk Allele
| T
|
| pValue
| 6.00E-019
|
| OR
| 1.28
|
| 95% CI
| 1.21-1.35
|
| GWAS snp
|
| PMID
| [PMID 19330030]
|
| Trait
| Breast cancer
|
| Title
| A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
|
| Risk Allele
| T
|
| P-val
| 1E-9
|
| Odds Ratio
|
|
Related to BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1
according to
omim 604370. See
also
Related to TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 3; TOX3
according to
omim 611416. See
also
| PharmGKB | PA161925624 |
| Name | |
| Annotation | This variant is significantly associated with risk for breast cancer from multiple large scale genome wide association studies. Carriers of the T allele had a 1.64-fold greater risk of estrogen receptor-positive breast cancer and were more likely to be diagnosed before the age of 60 years. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17529967; PubMed ID:17529974; PubMed ID:17997823 |
| Drugs | |
| Diseases | Breast Neoplasms |
| Curation Level | Curated |
