Have questions? Visit https://www.reddit.com/r/SNPedia

rs3817198

From SNPedia

Orientationplus
Stabilizedplus
Make rs3817198(C;C)
Make rs3817198(C;T)
Make rs3817198(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position1887776
GeneLOC102724536, LSP1
is asnp
is mentioned by
dbSNPrs3817198
ebirs3817198
HLIrs3817198
Exacrs3817198
Varsomers3817198
Maprs3817198
PheGenIrs3817198
hapmaprs3817198
1000 genomesrs3817198
hgdprs3817198
ensemblrs3817198
gopubmedrs3817198
geneviewrs3817198
scholarrs3817198
googlers3817198
pharmgkbrs3817198
gwascentralrs3817198
openSNPrs3817198
23andMers3817198
23andMe allrs3817198
SNP Nexus

SNPshotrs3817198
SNPdbers3817198
MSV3drs3817198
GWAS Ctlgrs3817198
GMAF0.2084
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS
SNP rs3817198
PubMedID [PMID 17529967OA-icon.png]
Condition Breast cancer
Gene LSP1
Risk Allele T
pValue 3.00E-009
OR 1.07
95% CI 1.04-1.11


OMIM153432
DescLYMPHOCYTE-SPECIFIC PROTEIN; LSP1
Variant
Relatedalso
OMIM114480
DescBREAST CANCER
Variant
Relatedalso
OMIM600185
DescBRCA2 GENE; BRCA2
Variant
Relatedalso
rs3817198 is a SNP in the LSP1 gene on chromosome 11. The less frequent allele rs3817198(C) increases risk of breast cancer by about +10% in Caucasians, but actually may be protective in women of African ancestry.[PMID 19656774OA-icon.png][PMID 22357627OA-icon.png]

[PMID 17529967OA-icon.png] rs3817198, a SNP associated with the LSP1 gene, was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 breast cancer samples.

[PMID 19656774OA-icon.png] Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers


[PMID 20145138] Common genetic variants associated with breast cancer and mammographic density measures that predict disease

[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk

[PMID 20699374OA-icon.png] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women


[PMID 21127985] Association of a LSP1 gene rs3817198T>C polymorphism with breast cancer risk: evidence from 33,920 cases and 35,671 controls

[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province


[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies


[PMID 21791674OA-icon.png] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium


[PMID 22357627OA-icon.png] Evaluation of 19 Susceptibility Loci of Breast Cancer in Women of African Ancestry


[PMID 17997823OA-icon.png] Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.


[PMID 18224312OA-icon.png] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.


[PMID 18326623OA-icon.png] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.


[PMID 18437204OA-icon.png] Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.


[PMID 18612136OA-icon.png] Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.


[PMID 18681954OA-icon.png] Breast cancer susceptibility loci and mammographic density.


[PMID 18708391OA-icon.png] Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.


[PMID 18772892OA-icon.png] Can genes for mammographic density inform cancer aetiology?


[PMID 18785201OA-icon.png] Novel breast cancer risk alleles and endometrial cancer risk.


[PMID 18973230OA-icon.png] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.


[PMID 19088016OA-icon.png] Genetic susceptibility loci for breast cancer by estrogen receptor status.


[PMID 19219042OA-icon.png] Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.


[PMID 19232126OA-icon.png] Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.


[PMID 19304784OA-icon.png] Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.


[PMID 19330030OA-icon.png] A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).


[PMID 19543528OA-icon.png] Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.


[PMID 19567422OA-icon.png] Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.


[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.


[PMID 19931039OA-icon.png] Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.


[PMID 20085711OA-icon.png] Leveraging genetic variability across populations for the identification of causal variants.


[PMID 20146796OA-icon.png] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.


[PMID 20237344OA-icon.png] Performance of common genetic variants in breast-cancer risk models.


[PMID 20484103OA-icon.png] Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.


[PMID 20605201OA-icon.png] Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.


[PMID 21596841OA-icon.png] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.


[PMID 22045194OA-icon.png] Combined effect of low-penetrant SNPs on breast cancer risk.


[PMID 22454379OA-icon.png] Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk.


[PMID 22532573OA-icon.png] The role of genetic breast cancer susceptibility variants as prognostic factors.


GET Evidence
rs3817198
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.1875
summary



[PMID 23756864OA-icon.png] Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer

GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele C
P-val 2E-11
Odds Ratio 1.07 [1.05-1.09]


[PMID 22910930OA-icon.png] Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.


[PMID 23577780OA-icon.png] Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.


[PMID 25784121] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography


[PMID 25881232OA-icon.png] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography


[PMID 26275715OA-icon.png] A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density


[PMID 26911390] TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk.