rs3817198 is a SNP in the LSP1 gene on chromosome 11. The less frequent allele rs3817198(C) increases risk of breast cancer by about +10% in Caucasians, but actually may be protective in women of African ancestry.[PMID 19656774][PMID 22357627]
[PMID 19656774] Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
[PMID 20145138] Common genetic variants associated with breast cancer and mammographic density measures that predict disease
[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk
[PMID 20699374] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
[PMID 21127985] Association of a LSP1 gene rs3817198T>C polymorphism with breast cancer risk: evidence from 33,920 cases and 35,671 controls
[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
[PMID 21791674] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
[PMID 22357627] Evaluation of 19 Susceptibility Loci of Breast Cancer in Women of African Ancestry
[PMID 17997823] Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18326623] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
[PMID 18437204] Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.
[PMID 18612136] Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.
[PMID 18681954] Breast cancer susceptibility loci and mammographic density.
[PMID 18708391] Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
[PMID 18772892] Can genes for mammographic density inform cancer aetiology?
[PMID 18785201] Novel breast cancer risk alleles and endometrial cancer risk.
[PMID 18973230] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
[PMID 19088016] Genetic susceptibility loci for breast cancer by estrogen receptor status.
[PMID 19219042] Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.
[PMID 19232126] Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.
[PMID 19304784] Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
[PMID 19330030] A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
[PMID 19543528] Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.
[PMID 19567422] Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 19931039] Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.
[PMID 20085711] Leveraging genetic variability across populations for the identification of causal variants.
[PMID 20146796] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
[PMID 20237344] Performance of common genetic variants in breast-cancer risk models.
[PMID 20484103] Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.
[PMID 20605201] Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
[PMID 21596841] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
[PMID 22045194] Combined effect of low-penetrant SNPs on breast cancer risk.
[PMID 22454379] Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk.
[PMID 22532573] The role of genetic breast cancer susceptibility variants as prognostic factors.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23756864] Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer
|Title||Large-scale genotyping identifies 41 new loci associated with breast cancer risk.|
|Odds Ratio||1.07 [1.05-1.09]|
[PMID 22910930] Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.
[PMID 23577780] Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.
[PMID 25784121] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography
[PMID 25881232] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography
[PMID 26275715] A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density
[PMID 26911390] TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk.