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rs3851179

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.5 0.85x decreased risk for Alzheimer's disease
(A;G) 1.5 0.85x decreased risk for Alzheimer's disease
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome11
Position86157598
is asnp
is mentioned by
dbSNPrs3851179
ebirs3851179
HLIrs3851179
Exacrs3851179
Varsomers3851179
Maprs3851179
PheGenIrs3851179
hapmaprs3851179
1000 genomesrs3851179
hgdprs3851179
ensemblrs3851179
gopubmedrs3851179
geneviewrs3851179
scholarrs3851179
googlers3851179
pharmgkbrs3851179
gwascentralrs3851179
openSNPrs3851179
23andMers3851179
23andMe allrs3851179
SNP Nexus

SNPshotrs3851179
SNPdbers3851179
MSV3drs3851179
GWAS Ctlgrs3851179
GMAF0.3297
Max Magnitude1.5
? (A;A) (A;G) (G;G) 28
rs3851179 is a SNP upstream of the PICALM gene.

A study of over 5,000 Alzheimer's disease patients (and over 10,000 controls) found a slight protective effect of the (A) allele of this SNP. rs3851179(A) carriers had a slightly decreased risk for Alzheimer's disease, with an odds ratio of 0.85 (CI: 0.8-0.9, p=1.9x10e-8).10.1038/ng.440[PMID 20554627OA-icon.png] The association of this SNP and late-onset Alzheimer's disease was replicated over a total of another 1829 cases (and 2576 controls).

GWAS snp
PMID [PMID 19734902OA-icon.png]
Trait Alzheimer's disease
Title Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
Risk Allele
P-val 1E-9
Odds Ratio 1.16 [1.11-1.22]


[PMID 20697030OA-icon.png] Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

[PMID 20951388] Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese


[PMID 21321396OA-icon.png] Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions


[PMID 21912625OA-icon.png] An exploratory study on CLU, CR1 and PICALM and Parkinson disease


[PMID 22715855] Lack of association of the PICALM rs3851179 polymorphism with Parkinson's Disease in the Greek Population


[PMID 20451875OA-icon.png] Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.


[PMID 20738160] Association analysis between the rs11136000 single nucleotide polymorphism in clusterin gene, rs3851179 single nucleotide polymorphism in clathrin assembly lymphoid myeloid protein gene and the patients with schizophrenia in the Chinese population.


[PMID 20739100OA-icon.png] Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.


[PMID 21297266] Implication of a genetic variant at PICALM in Alzheimer's disease patients and centenarians.


[PMID 21347408OA-icon.png] Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.


[PMID 21358043] PICALM and CR1 variants are not associated with sporadic Alzheimer's disease in Chinese patients.


[PMID 21379329OA-icon.png] Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.


[PMID 21390209OA-icon.png] Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.


[PMID 21726919] CR1 genotype is associated with entorhinal cortex volume in young healthy adults.


[PMID 22015308] Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.


[PMID 23036585OA-icon.png] Exploratory analysis of seven Alzheimer's disease genes: disease progression


[PMID 23040034] Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup


GET Evidence
rs3851179
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.742188
summary



[PMID 22402018] Implication of common and disease specific variants in CLU, CR1, and PICALM


[PMID 23419238OA-icon.png] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms


[PMID 22943764OA-icon.png] Identification and confirmation of an exonic splicing enhancer variation in exon 5 of the Alzheimer disease associated PICALM gene


[PMID 23572399] PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population


[PMID 23650005] Lack of association of CR1, PICALM and CLU gene polymorphisms with Alzheimer disease in a Polish population


[PMID 24618820OA-icon.png] Genetics of PICALM Expression and Alzheimer's Disease


[PMID 22005930OA-icon.png] Genome-wide association study of Alzheimer's disease with psychotic symptoms.


[PMID 23180304] Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.


[PMID 24788522] Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity


[PMID 25169757OA-icon.png] An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform


[PMID 20558387OA-icon.png] Genetic variation and neuroimaging measures in Alzheimer disease.


[PMID 25189118] Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease


[PMID 26434199] LACK OF ASSOCIATIONS BETWEEN CLU AND PICALM GENE POLYMORPHISMS AND ALZHEIMER'S DISEASE IN A TURKISH POPULATION


[PMID 26611835] Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1.


[PMID 26889634] Investigation of Genetic Variants Associated with Alzheimer Disease in Parkinson Disease Cognition.