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rs4054823

From SNPedia

Associated with aggressive form of prostate cancer
Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal risk of aggressive form of prostate cancer
(C;T) 0 normal risk of aggressive form of prostate cancer
(T;T) 2 1.26x higher risk of aggressive form of prostate cancer
ReferenceGRCh38 38.1/141
Chromosome17
Position13721707
is asnp
is mentioned by
dbSNPrs4054823
ebirs4054823
HLIrs4054823
Exacrs4054823
Varsomers4054823
Maprs4054823
PheGenIrs4054823
hapmaprs4054823
1000 genomesrs4054823
hgdprs4054823
ensemblrs4054823
gopubmedrs4054823
geneviewrs4054823
scholarrs4054823
googlers4054823
pharmgkbrs4054823
gwascentralrs4054823
openSNPrs4054823
23andMers4054823
23andMe allrs4054823
SNP Nexus

SNPshotrs4054823
SNPdbers4054823
MSV3drs4054823
GWAS Ctlgrs4054823
GMAF0.4421
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs4054823 is a SNP in chromosomal region 17p12.

This SNP is associated with risk of aggressive prostate cancer. Most prostate cancers proceed slowly and can be successfully treated even if not detected early. A subset of prostate cancers are an aggressive form which is harder to treat, especially if not detected early. The aggressive form of prostate cancer accounts for an estimated 27,000 deaths annually in the US.

A study of 4,829 and 12,205 patients with more and less aggressive disease, respectively, found that the frequency of rs4054823(T;T) was consistently higher among patients with more aggressive compared with less aggressive disease in each of the seven populations studied (overall p = 2.1 x 10e-8). This is not a predictor of increased risk of prostate cancer. Instead, those who do get prostate cancer have a higher risk of it being the aggressive type if they have the risk factor. Those with the risk factor can benefit from more frequent prostate cancer exams, and more aggressive treatment if prostate cancer is found.[PMID 20080650OA-icon.png]

In the news: Gene may pinpoint most aggressive prostate cancer.


[PMID 21308149OA-icon.png] Impact of genotyping on outcome of prostatic biopsies: a multicenter prospective study

[PMID 21367958OA-icon.png] Association of prostate cancer risk Loci with disease aggressiveness and prostate cancer-specific mortality.

[PMID 21520160] Prostate cancer risk variants are not associated with disease progression.