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rs41291556

From SNPedia

Clopidogrel (Plavix®)
Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 3 CYP2C19*8 homozygote
(C;T) 2 carrier of one CYP2C19*8 allele, considered a "slow metabolizer"
(T;T) 0 normal
ReferenceGRCh38 38.1/142
Chromosome10
Position94775416
GeneCYP2C19
is asnp
is mentioned by
dbSNPrs41291556
ebirs41291556
HLIrs41291556
Exacrs41291556
Varsomers41291556
Maprs41291556
PheGenIrs41291556
hapmaprs41291556
1000 genomesrs41291556
hgdprs41291556
ensemblrs41291556
gopubmedrs41291556
geneviewrs41291556
scholarrs41291556
googlers41291556
pharmgkbrs41291556
gwascentralrs41291556
openSNPrs41291556
23andMers41291556
23andMe allrs41291556
SNP Nexus

SNPshotrs41291556
SNPdbers41291556
MSV3drs41291556
GWAS Ctlgrs41291556
GMAF0.001837
Max Magnitude3
CPMC Logo.png

This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
Additional information is available here

Defines the CYP2C19 variant known as CYP2C19*8.

Carriers of the rs41291556(C) allele may have decreased activity and poor metabolizer (PM) phenotype. This variant is associated with a dramatic (approximately 90% and 70%) reduction in the metabolism of S-mephenytoin and tolbutamide in vitro.[PMID 10411572]



GET Evidence
CYP2C19-W120R
aa_change Trp120Arg
aa_change_short W120R
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0078125
summary



Clopidogrel Efficacy