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rs4149268

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;G) 2 associated with higher HDL cholesterol
(G;G) 2 associated with higher HDL cholesterol


Make rs4149268(A;A)
ReferenceGRCh38 38.1/141
Chromosome9
Position104884939
GeneABCA1
is asnp
is mentioned by
dbSNPrs4149268
ebirs4149268
HLIrs4149268
Exacrs4149268
Varsomers4149268
Maprs4149268
PheGenIrs4149268
hapmaprs4149268
1000 genomesrs4149268
hgdprs4149268
ensemblrs4149268
gopubmedrs4149268
geneviewrs4149268
scholarrs4149268
googlers4149268
pharmgkbrs4149268
gwascentralrs4149268
openSNPrs4149268
23andMers4149268
23andMe allrs4149268
SNP Nexus

SNPshotrs4149268
SNPdbers4149268
MSV3drs4149268
GWAS Ctlgrs4149268
GMAF0.421
Max Magnitude2
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 18193043]
Trait HDL cholesterol
Title Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Risk Allele C
P-val 1E-10
Odds Ratio 0.82 [NR] mg/dl higher

G allele is associated with 0.82mg/dl increase in HDL cholesterol (good cholesterol). [PMID 18193043]


[PMID 21738485OA-icon.png] Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 19060910OA-icon.png] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.


[PMID 19185284OA-icon.png] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.


[PMID 19435741OA-icon.png] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.


[PMID 19606474OA-icon.png] A survey of ABCA1 sequence variation confirms association with dementia.


[PMID 19802338OA-icon.png] Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.


GET Evidence
rs4149268
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.554688
summary