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rs4293393

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0.76x reduced risk of CKD for C allele
(C;T)
(T;T) 0  1.25x Increased Risk of CKD for T allele in Icelandic study
ReferenceGRCh38 38.1/141
Chromosome16
Position20353266
GeneUMOD
is asnp
is mentioned by
dbSNPrs4293393
ebirs4293393
HLIrs4293393
Exacrs4293393
Varsomers4293393
Maprs4293393
PheGenIrs4293393
hapmaprs4293393
1000 genomesrs4293393
hgdprs4293393
ensemblrs4293393
gopubmedrs4293393
geneviewrs4293393
scholarrs4293393
googlers4293393
pharmgkbrs4293393
gwascentralrs4293393
openSNPrs4293393
23andMers4293393
23andMe allrs4293393
SNP Nexus

SNPshotrs4293393
SNPdbers4293393
MSV3drs4293393
GWAS Ctlgrs4293393
GMAF0.1685
Max Magnitude0
? (C;C) (C;T) (T;T) 28

23andMe blog each G at rs4293393 decreased the odds of chronic kidney disease by 24%. Approximately 18% of people with European ancestry have at least one G at this SNP. [1]

DeCode reports that the T allele of rs4293393 is associated with kidney stones and chronic kidney disease. [2] This SNP may also be associated with susceptibility to gout, hypertension, and diabetes. [PMID 20686651OA-icon.png]


[PMID 19959715OA-icon.png] Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD


[PMID 20686651OA-icon.png] Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones-Role of Age and Comorbid Diseases


[PMID 20222955OA-icon.png] A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.