|(A;G)||2||3.5x risk of hep-cancer in cirrhosis patients; higher glioma risk|
|(G;G)||2.1||3.5x risk of hep-cancer in cirrhosis patients; higher glioma risk; 3x higher gallbladder cancer risk in females|
A study of 2 Caucasian populations of patients with alcoholic cirrhosis indicates that, for these patients, the presence of the risk allele rs4444903(G) increases the chances of developing hepatocellular carcinoma (liver cancer). After adjusting for age, sex, race, etiology, and severity of cirrhosis the number of (G) copies led to an odds ratio for either (G;G) or (A;G) genotypes versus the (A;A) genotype of 3.49 (CI: 1.29-9.44, p=.01). [PMID 18167406]
In another study, analysis of 197 glioma patients showed that the rs4444903(G) allele conferred higher risks for gliomas (odds ratio 1.32, CI: 1.04-1.67), glioblastomas (OR, 1.47, CI: 1.02-2.10), and oligodendrogliomas (OR, 1.55, CI: 1.07-2.23). In general, the risk was about the same for a carrier or one or two (G) alleles, however, no significant association was observed with patients' overall survival.[PMID 17473192]
effects lots of no known risk pmids15373782 15729146 16214932 16214933 16214934 16214935 16217151 16217152 16217153
[PMID 20487573] Association between EGF +61 G/A and glioma risk in a Chinese population
[PMID 19319135] Common genetic variability in ESR1 and EGF in relation to endometrial cancer risk and survival.
[PMID 21567271] Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population
[PMID 22122913] Association between the epidermal growth factor rs4444903 G/G genotype and advanced fibrosis at a young age in chronic hepatitis C
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[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 19822020] Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.
[PMID 20203692] A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population.
[PMID 21440548] A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma.
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[PMID 23403233] EGF +61A>G polymorphism and gastrointestinal cancer risk: A HuGE review and meta-analysis
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[PMID 23201894] Lack of association between EGF +61A>G polymorphism and melanoma susceptibility in Caucasians: a HuGE review and meta-analysis.
[PMID 23645212] Association between epidermal growth factor gene rs4444903 polymorphism and risk of glioma.
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[PMID 24754849] Polymorphism in the epidermal growth factor gene is associated with pre-eclampsia and low birthweight
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[PMID 24558090] Genetic markers of bevacizumab-induced hypertension
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|Disease||cetuximab response - Efficacy|
|CLNDBN||cetuximab response - Efficacy|
|CLNSRC||PharmGKB Clinical Annotation PharmGKB|