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rs45477792

From SNPedia

Merged intors17221812
Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common
(C;T) resistant to drug block
(T;T) not seen (too rare)
ReferenceGRCh38 38.1/141
Chromosome12
Position5045742
GeneKCNA5
is asnp
is mentioned by
dbSNPrs45477792
ebirs45477792
HLIrs45477792
Exacrs45477792
Varsomers45477792
Maprs45477792
PheGenIrs45477792
hapmaprs45477792
1000 genomesrs45477792
hgdprs45477792
ensemblrs45477792
gopubmedrs45477792
geneviewrs45477792
scholarrs45477792
googlers45477792
pharmgkbrs45477792
gwascentralrs45477792
openSNPrs45477792
23andMers45477792
23andMe allrs45477792
SNP Nexus

SNPshotrs45477792
SNPdbers45477792
MSV3drs45477792
GWAS Ctlgrs45477792
StatusMerged into rs17221812
Max Magnitude0
This SNP, also known as P532L, affecting an amino acid in exon 1 of the KCNA5 potassium channel gene, may mediate the response to drugs such as quinidine.

The risk allele is rs45477792(T), and carriers receiving quinidine or propafenone for the treatment of cardiac arrhythmias may be resistant to the drug (and thus treatment). Note that this allele is rare; it was not observed in Caucasian or Asian populations, however it is reported to be present at a frequency of 0.8% (i.e. less than 1%) among African-Americans. [PMID 15735608]

Neighborrs45438698
Distance138